Lab 3 - Hypertension Flashcards
Hydrochlorothiazide - MoA
Thiazide diuretic. Inhibit Na+, Cl- symporter and increase sodium excretion
Hydrochlorothiazide - Dose and route
12,5 mg orally
Hydrochlorothiazide - Adverse effects
Hyponatremia Hypokalemia and metabolic alkalosis Hypomagnesemia Hypercalcemia Hyperuricemia Hypertrigyceridemia Hyperglycemia
Hydrochlorothiazide - Contraindications
Liver and kidney failure Diabetes Gout Allergy to sulfonamides Obs in pts with urinary issues (overactive bladder, BPH, especially in elderly)
Hydrochlorothiazide - Interactions
- ACE inhibitors have opposite effect on potassium
- Increase serum levels of lithium by increasing reabsorption
- Hypotensive effect decreased by NSAIDs and augumented by ACE inhibitors
Captopril - Dose and route
12,5 mg X 2 PO
Propanolol - Dose and route
40 mg orally. Increase dose to not more than 160mg x 2
Amlodipine - MoA
Dihydropyridine calcium channel blocker. Arteriolar vasodilation
Amlodipine - Dose and route
5 mg orally
Amlodipine - Adverse effects
Hypotension and reflex tachycardia Dizziness Flushing Headache Peripheral edema Gingival hyperplasia Constipation
Amlodipine - Contraindications
Severe hypotension
Cardiogenic shock
Acute MI
Aortastenosis
Amlodipine - Interactions
Serum levels increased by azole antifungal agents and cimetidine
Methyldopa - MoA
alpha 2 agonist. converted to methylnorepinephrine which activated a2
Methyldopa - Dose and route
125mg x 2 orally
Methyldopa - Adverse effects
Sedation
Orthostatic hypotension
Dry mouth
Headache
Immunologic effects including;
coombs positive hemolytic anemia, autoimmune hepatitis, other organ dysfunction.
Lupus-like syndrome