Lab

Question 1

OCR

Answer 1

rate of oxygen consumption (OCR) is indicative of mitochondrial respiration

Question 2

ECAR

Answer 2

rate of acid efflux (ECAR) is a measure of lactic acid formed during glycolytic energy metabolism.

Question 3

Energy metabolism

Answer 3

Energetic changes/ Phenotypic changes

Question 4

ATP/ O2

Answer 4

glycolytic metabolism - 1 ATP/O2

mitochondrial respiration - 5 ATP/O2

Question 5

SNP P2X7R

Answer 5

rs 37 511 43

Question 6

Th1

Answer 6

Stat 1, stat 4
T-bet
IFN g

Question 7

Th17

Answer 7

Tgf-b, IL 1b, IL 6,
ROR g,
Stat 3
IL 17, IL 21-22

Question 8

Th2

Answer 8

Gata3, stat6

IL 4, 5, 9, 13

Question 9

Treg

Answer 9

TGF b, IL 2, ATRA
Foxp3, stat 5
IL 10, TGF b

Question 10

ABM (for anti-bm12) mice

Answer 10

TCR transgenic mice specific for I-Abm12 expressed on B6.C.H-2bm12 mice

Question 11

CTOT Primary Outcome Measures:

Answer 11

Composite Measure of Transplant Health [ Time Frame: 12 months after enrollment in study ]
A composite of incidence of the following:
1. Death,
2. Re-transplantation or re-listed for transplantation,
3. Biopsy proven acute rejection (BPAR) of > 2R,
4. Episode of rejection associated with hemodynamic compromise,
5. Coronary artery vasculopathy defined by a change in MIT of >0.5 mm between study entry and 12 months.