Lab 1 - Peripheral Blood Morphology Flashcards
1
Q
Anisocytosis
A
- Variation in RBC Size
- Range of RBC sizes measured by Red Cell Distribution Weight (RDW)
2
Q
Microcytosis
A
- Small RBCs
- Can measure using Median Corpuscular Volume (MCV)
- Associated with
- Iron deficiency
- Thalassemias
- Sideroblastic anemia
3
Q
Macrocytosis
A
- Larger MCVs
- Associated with:
- Elevated Reticulocyte count
- B12/Folate deficiency
- Liver disease
- Thyroid disease
- Chemotherapy
- Anti-retrovirals (AZT)
4
Q
Hypochromasia
A
- RBC does not produce enough Hb
- Central pallor >1/3 RBC diameter
- Can measure by Mean Corpuscular Hemoglobin (MCH)
5
Q
Polychromasia
A
- RBCs have blue tinge
- are larger
- are probably Reticulocytes
6
Q
Poikilocytosis
A
- Cells that vary widely in shape
- “Shape has a P”
7
Q
Target Cells
A
- Associated with
- Liver Disease
- Thalassemias
- HbC
- Post-splenectomy
8
Q
Spherocytes
A
- Loss of central pallor
- Associated with:
- Hereditary spherocytosis
- Autoimmune hemolysis
- will have smaller cells in this case
9
Q
Schistocytes
A
- “Helmet cells”
- Hallmark of: Microangiopathic Hemolytic Anemica (MAHA)
10
Q
Echinocytes (Burr cells)
A
- Small, regular projections
- seen in renal disease
11
Q
Acanthocytes (spur cells)
A
- Large, irregular projections
- seen in liver disease
12
Q
Teardrop cells
A
- Seen in Myelophthisic processes
- diseases of bone marrow infiltration
- Seen in
- Myelofibrosis
- Tumor metastatic to marrow
- Granulomatous diseases
- Leukemias and lymphomas
- Massive splenomegaly
13
Q
Howell-Jolly Bodies
A
- Peripheral, small, round, purple inclusions in RBCs
- Are nuclear remnants
- Seen with
- Splenectomy
- During splenic hypofunction
14
Q
Rouleaux
A
- Linear cell arrangement
- “Coins on a plate”
- Associated with
- Increased immunoglobulin diseases
- Multiple Myelomas
- Waldenstrom’s Macroglobulinemia
- Severe hypoalbuminemia
- Increased immunoglobulin diseases
15
Q
Agglutination
A
- Occurs when RBCs coated with IgM
- clumps, not orderly like Rouleaux
