LA Flashcards
Protein binding directly correlates to…
LA Duration
Lipid solubility directly correlates to…
LA potency
Speed of onset directly correlates to…
LA pKA
Onset of action indirectly correlates to…
LA Ionization
In Time I Can Please Everyone But Sally & Shelby
IV Tracheal Intercostal Caudal Paracervical Epidural Brachial Plexus Subarachnoid, Sciatic, Femoral Subcutaneous
Blockade occurs along…
Nodes of myelin sheath (nodes of ranvier)
Therapeutic Lidocaine plasma concentration
5 mcg/ml or less
Clinical signs with lidocaine 5 mcg/ml or less
Lightheadedness, tinnitus, circumoral and tongue numbness
Clinical signs with lidocaine plasma concentration 5-10 mcg/ml
Visual disturbances
Clinical signs with lidocaine concentration 10 mcg/ml
Muscular twitching
Clinical signs with lidocaine concentration 10-15 mcg/ml
Convulsions
Clinical signs with Lidocaine plasma concentration 15 mcg/ml
Unconsciousness
Clinical signs with lidocaine plasma concentration 15-20 mcg/ml
Coma
Clinical signs with lidocaine plasma concentration 20-25 mcg/ml
Respiratory arrest
Clinical signs with plasma concentration 25 mcg/ml
CVS depression
Treatment of LAST
Airway, seizure suppression, CPR, 20% lipid emulsion
Lipids given in treatment of LAST
1.5 ml/kg initial bolus followed by 0.25 ml/kg/min for 30-60 min
Bolus could be repeated 1-2 times for persistent asystole
Infusion rate could be increased if BP declines
Lidocaine (2345678)
MW: 234 g/mol
% protein bound: 56
PKA: 7.8
