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Regional > LA > Flashcards

LA Flashcards

0
Q

Protein binding directly correlates to…

A

LA Duration

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1
Q

Lipid solubility directly correlates to…

A

LA potency

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2
Q

Speed of onset directly correlates to…

A

LA pKA

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3
Q

Onset of action indirectly correlates to…

A

LA Ionization

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4
Q

In Time I Can Please Everyone But Sally & Shelby

A 
IV
Tracheal
Intercostal
Caudal
Paracervical
Epidural
Brachial Plexus
Subarachnoid, Sciatic, Femoral
Subcutaneous
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5
Q

Blockade occurs along…

A

Nodes of myelin sheath (nodes of ranvier)

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6
Q

Therapeutic Lidocaine plasma concentration

A

5 mcg/ml or less

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7
Q

Clinical signs with lidocaine 5 mcg/ml or less

A

Lightheadedness, tinnitus, circumoral and tongue numbness

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8
Q

Clinical signs with lidocaine plasma concentration 5-10 mcg/ml

A

Visual disturbances

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9
Q

Clinical signs with lidocaine concentration 10 mcg/ml

A

Muscular twitching

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10
Q

Clinical signs with lidocaine concentration 10-15 mcg/ml

A

Convulsions

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11
Q

Clinical signs with Lidocaine plasma concentration 15 mcg/ml

A

Unconsciousness

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12
Q

Clinical signs with lidocaine plasma concentration 15-20 mcg/ml

A

Coma

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13
Q

Clinical signs with lidocaine plasma concentration 20-25 mcg/ml

A

Respiratory arrest

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14
Q

Clinical signs with plasma concentration 25 mcg/ml

A

CVS depression

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15
Q

Treatment of LAST

A

Airway, seizure suppression, CPR, 20% lipid emulsion

16
Q

Lipids given in treatment of LAST

A

1.5 ml/kg initial bolus followed by 0.25 ml/kg/min for 30-60 min
Bolus could be repeated 1-2 times for persistent asystole
Infusion rate could be increased if BP declines

17
Q

Lidocaine (2345678)

A

MW: 234 g/mol
% protein bound: 56
PKA: 7.8

Regional (4 decks)

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