LA Flashcards
Briefly explain the process of depolarization
Na+ enters cell, K+ leaves cell
What is the mode of action of LA agents:
a) Alter resting potential of cell membrane
b) Alter threshold potential
c) Decrease rate of depolarization
d) Prolonging the phase of depolarization
c) Decrease the rate of depolarization to a level which becomes too slow to reach threshold of action potential
Which is able to diffuse across membrane:
a) ionic particles
b) Non-ionic particles
Non ionic
The preferred LAs used in clinical practices are
a) Esters
b) Amides
b) Amides
Which of these does not contain adrenaline
a) Lignocaine
b) Mepivacaine
c) Prilocaine
d) Articaine
Prilocaine
Where is Articaine metabolised?
Liver and Plasma
Duration of Lignocaine with Adrenaline:
60-90 mins
Lignocaine is excreted by the:
Kidneys
What is the spposed advantage of mepivacaine over lignocaine?
Longer lasting as less vasodilator effect
Priolocaine is metabolised in the and excreted in.
Lungs and Liver
Urine
Prilocaine is implicated in the formation of:
It is therefore contraindicated in:
Methaemaglobin
Pregnant
What is used to reverese methamaglobinaemia
Methylene blue
Why is articaine thought to be less toxic than lignocaine?
Shorter half life
Articaie is not recommended for whom:
- Pregnant
- Under 4
- Sulphur allergy
- Pseudocholinesterase deficiency
- Methaemogobinaemia
Articaine is metabolised by:
Liver, lung, plasma
Which is not used in routine dentistry:
a) Mepivacaine
b) Articaine
c) Bupivicaine
d) Lignocaine
c) Bupivacaine
How is LA dosage calculated?
LA% x cartridge volume x 10
What is the absolute maximum safe dose of Lignocaine
500mg
What is the absolute maximum safe dose of articaine?
700mg
What is the maximum recommended safe dose of Lignocaine per kg body weight:
7.0mg
Adrenaline is a
a) Bronchoconstrictor
b) Bronchodilator
b) Bronchodilator
What effects does adrenaline have on the heart
- Increase rate and contractility eg cardiac output
- Increased workload and oxygen demand
- May induce angina or arrhythmias in susceptible patients
- May also increase blood pressure
- MUST USE PRECAUTION if someone is being prescribed non-selective beta blockers
The maximum recommended adrenaline dose for healthy patients is:
0.2mg