L84 - Viral Pathogenesis 2

Question 1

Gnetic factors that influence susceptibility to viral infection?

Answer 1

inherited defects (absence of Ig class)

Polymorphisms in genes controlling immune respnse (i.e. MHC genes)

Interferon-inducible genes (MxA and MxB)

Receptor genes i.e. CCR5

Question 2

Non-genetic factors influencing susceptibiliy to viral infection:

Answer 2

age (newborn and elderly are more susceptible i.e. immature and waning immune response, however the young suffer less from immunopathology

Malnutrition (decreases resistance)

Hormones/Pregnancy (males and pregnant women are more susceptibl)

Dual Infections (may result in more severe disease)