L78 - Systematic Reviews and Analyses

Question 1

What is a systematic review?

Answer 1

Literature view that focuses on a single question. It identifies, appraises, selects, and synthesises high-quality evidence relevant to that question.

Question 2

Does a Systematic Review reviewclinical trial data or observational data?

Answer 2

both

Question 3

What is a Meta-Analysis?

Answer 3

Statistical aspect of systematic review. Analysis of combined data from multiple studies.

Question 4

What are the 4 purposes of a Meta-analysis?

Answer 4

1. Increased Power
2. Resolve uncertainty
3. Improve estimates of effect size
4. Precision

Question 5

How can you measure the outcome, aka weighted average effect size?

Answer 5

Relative measure, i.e. RR, OR

Absolute Measure, i.e. mean difference

Question 6

What can be used to indicate the weighting of individual studies?

Answer 6

Sample size

Inverse Variance

Question 7

What can be used to measure the variability in effect size, aka heterogeneity

Answer 7

Chi-square test

Fixed-effects or random-effects modelling