L7 - Stimulus Recognition Flashcards

1
Q

LGN layered structure

A

6 layers
4 layers receive input from Parvocellular ganglion cells
2 layers receive input from Magnocellular ganglion cells

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2
Q

What type of input does the LGN have?

A

Monocular input

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3
Q

In the LGN which layers receive input from which eye?

A

Layers alternate input from each eye

  • One layer receives input from contralateral eye
  • Another layer receives input from ipsilateral eye
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4
Q

How is the LGN organised?

A

Retinotopically

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5
Q

What is the thalamic relay station in the LGN?

A

Ganglion cell axons make 1:1 connections with LGN projection neurons
Receptive fields of LGN neurons are similar to receptive fields of retinal ganglion cells

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6
Q

Where does the LGN receive 60% of its synaptic input from?

A

From the cortex

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7
Q

What are the two visual pathways in the cortex?

A

Ventral

Dorsal

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8
Q

What is the ventral visual pathway?

A

What
Object feature stream
Inferior temporal

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9
Q

What is the dorsal visual pathway?

A

Where
Spatial location stream
Posterior parietal

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10
Q

Ventral visual pathway method

A
  1. Parvocellular ganglion cell
  2. LGN Parvo
  3. V1 cortical area
  4. V2 cortical area
  5. V4 – cortical area
  6. Inferior temporal cortex – temporal pathway (what)
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11
Q

What two things increase along the ventral visual pathway?

A

Increase in complexity of responses of neurons along the ventral stream
Increase in the receptive field size of neurons along the ventral stream

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12
Q

What three things do we need to understand for object recognition?

A

Find single neurons (or population of neurons) that specifically respond to presentation of a specific object and understand their presynaptic neuronal circuits
Understand how activation of these neurons causes particular behavioural reactions
One neuron vs population of neurons

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13
Q

Example of understanding object recognition

A

Subject looks at an image of a particular object.

  • Few neurons in higher cortical areas fire
  • Stimulation of the same neurons causes perception of the same object
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14
Q

What is orientation invariance?

A

Can recognise objects in their natural orientation

Use this knowledge to recognise an unnatural orientation

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15
Q

What is scale invariance?

A

Can recognise objects independently on their size

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16
Q

Hierarchical model of object recognition

A
  1. Detection of edges
  2. Detection of edges and contours
  3. Detection of object parts
  4. Detection of objects from one point of view
  5. View-invariant object detection – e.g. particular person, a car
  6. Categorisation
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17
Q

What increases along the hierarchical model?

A

Increase in stimulus complexity

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18
Q

What experiments were used to test the object recognition model?

A

Lesions in inferior temporal cortex decrease the ability to recognise objects
Mainly studied by mathematical modelling and electrophysiology

19
Q

What are the three key features of cortical structure?

A

Layering
- Different layers have different functions
Columns
- Parts of the brain that have neurons that have very similar functions
Blobs
- Colour

20
Q

Information flow in the cortex

A

In parts of the cortex there are more cell bodies than in other areas
Different types of upstream cells send their projections to different layers
Interneurons receive input from one layer and send projections to a different layer
Different layers send their outputs to different areas of the brain

21
Q

What are the three subtypes of columnar organisation in the cortex?

A

Ocular dominance column
Orientation columns – direction
Blobs – colour

22
Q

What experiments where done to study ocular dominance?

A

Inject radioactive proline in one eye

Inject radioactive glucose in the cortex and stimulate one eye with light

23
Q

Ocular dominance columns - inject radioactive proline experiment

A

It enters ganglion cells and diffuses along the axon
Enters LGN and crosses the synapses
Enters LGN neurones
Use optic visualisation to observe radioactivity – stripes

24
Q

Ocular dominance columns - inject radioactive glucose experiment

A

Enters neurons that are currently active as they need glucose
Use optic visualisation to observe radioactivity – stripes

25
Q

Ocular dominance columns in the visual cortex

A

Different parts of the brain within the same cortical area receive input from only one eye
Each column in the V1 cortex receives inputs from either ipsilateral or contralateral eye
Different layers of LGN already receive input from different eyes

26
Q

What are orientation columns? – columnar architecture in MT cortex

A

Neighbouring parts of the brain have neurons with slightly different properties
Therefore respond differently to motion in different orientations
This also occurs in the LGN

27
Q

What are blobs?

A

Parts of the brain have different properties that are important for processing information about colour

28
Q

What is a hypercolumn?

A
Three types of columns
- Blobs 
- Ocular dominance columns 
- Orientation columns 
This unit can process any type of information
29
Q

What experiments did Hubel and Wiesel carry out?

A

Worked on V1 cortex in cat

Recorded response of individual neurones to different direction of stimulus

30
Q

Example of a Hubel and Wiesel experiment

A

Response of V1 neuron to bars of different orientations
Can plot on graph of stimulus orientation/neural response
Gives a bell shaped curve
These V1 neurons cells are called simple cells

31
Q

Where are simple cells found?

A

Localised in layers 4 and 6 of V1 cortex

32
Q

What do simple cells respond to?

A

Respond to a bar in certain orientation presented in the center of the receptive field

33
Q

Receptive fields of ganglion cells and LGN neurones

A

Receptive field are round shaped
One response in the centre of the cell
Opposite response on the outside of cell

34
Q

Receptive field of simple cells

A

Receptive fields are elongated in shape

Different response along midline vertically

35
Q

Probable circuit mechanism of simple cell receptive field

A

Several neurons that have receptive fields orientated in one line in the LGN feed to the same neuron in the visual cortex
Allows elongation of receptive field in one direction

36
Q

What do complex cells do?

A

Respond to a bar in certain orientation presented anywhere in the receptive field

37
Q

Where are complex cells located?

A

Localised in layers 2, 3 and 5

38
Q

Possible circuit basis of complex cell receptive field

A

Complex cells collect information from many simple cells with similar orientation of receptive field

39
Q

What is a hypercomplex?

A

End stopped complex cell
If you have a bar in a certain orientation you have a response
As the bar goes away from receptive field – cell stops responding
If you change the orientation of the bar away from the receptive field – cell starts responding again

40
Q

Receptive fields downstream of V1

A

Increase in complexity

Receptive fields increase in size

41
Q

Face sensitive neurons in the temporal lobe

A

Respond to faces

If you remove characteristic parts of the face the neurons respond less and less

42
Q

What is a grandmother neuron?

A

Neuron in brain fires when a specific thing is seen or heard – e.g. Grandmother
- 1 or a few neurons recognise a particular object
The neurons also show adaptation – initial firing is high then drops very quickly

43
Q

What are the problems with the hierarchical model?

A

Still poor in scale and orientation invariance
Does not take into account feedbacks from higher cortical areas
Need experimental validation which is difficult because need to record pre and postsynaptic responses