L6 Stereochemistry in Drug Design SB Flashcards
1
Q
Stereoisomers are…
A
Isomers with the same connectivity but a different 3D spacial arrangement of atoms
2
Q
State 4 methods to obtaining optically pure Naproxen
A
- Using physical properties of racemates to separate desired racemates from undesirable racemates.
- Using naturally occurring compounds
- Using chromatography to separate desired racemate from the mixture by using a Stationary phase
- Using N-propylglucosamine to make the soluble R salt and the crystalline, insoluble S salt
3
Q
What mechanism do you need to know? Draw it and check it.
A
Omeprazole
