L6- Regulation Of Enzyme Activity

Question 1

Types of regulation

Answer 1

Zymogen activation, Covalent modification, Allosteric Modulation, Feedback inhibition, enzyme synthesis

Question 2

What is covalent modification?

Answer 2

Addition and removal of phosphate groups to serine and tyrosine

Question 3

What is allosteric modulation?

Answer 3

Binding of the effector to the allosteric site, to affect catalytic acitivity

Question 4

What is Feedback inhibition?

Answer 4

when the end products bind at the allosteric sites

Question 5

What is the commited-step enzyme?

Answer 5

first irreversible enzyme unique to the pathway, not rate limiting step

Question 6

Types of inhibitors?

Answer 6

Competitive and non-competitive

Question 7

What do statin drugs do?

Answer 7

Competitively inhibit the rate limiting step

Question 8

Competitive inhibition affect on Vmax and Km?

Answer 8

Vmax same, Km increase

Question 9

Non-competitive inhibition on Vmax and Km?

Answer 9

Vmax lower, Km same