L6-7: Immune Regulation

Question 1

Foxp3 Treg cells constitutively express

Answer 1

CD25 - IL-2 receptor alpha chain as well as others markers such as CTLA-4

Question 2

T or F:

T cells directed to self-Ag are present in normal animals

Answer 2

True, these are neutered by Treg cells

Question 3

Foxp3 targets

Answer 3

Molecules involved in signalling/proliferation are downregulated e.g. Zap70, Jak2, IL-2

Question 4

Suppression by Treg is mediated by

Answer 4

inhibitory cytokines e.g. IL-10, TGF-beta
CTLA4 interactions
other things

Question 5

IL-10 function

Answer 5

Inhibitory cytokine that inhibits DC and macrophages, and Ag presentation

Question 6

TGF-beta function

Answer 6

Inhibits T cell division and effector function

Inhibits activation of macrophages

Question 7

CTLA4 function of Treg cells

Answer 7

Interaction with and subsequent downregulation of CD80/86 on DC

Question 8

Treg and NK cell relationship

Answer 8

Treg cells dampen the inflammatory response in lymph nodes and facilitate entry of immune cells into infected tissue

Question 9

Development of gut Treg requires

Answer 9

Binding of short chain fatty acids to FFAR/GPCR43 expressed on Treg cells