L59 Cancer Nutrition

Question 1

heterocyclic amines

Answer 1

heated red meats

amine + creatine

DNA adducts and breaks

temp is main factor

precarcinogens: converted by p450

Question 2

polycystic aromatic hydrocarbons

Answer 2

PAH

-fat from mean drops onto fire and carrie din smoke…bulky fxn in depurination or stable adducts

Question 3

sodium nitrite

Answer 3

preservative

nitrite is the conj base of nitrous acidL HNO2
-deaminates 1o aromatic amines, base mispairing

adducts in colon cells

Question 4

salts ans alcohol

Answer 4

salts demage cell lining leading to icreased growth
-chronic inflammation- pylori helicobacter

alcohol increase levels of POS DNA breaks adducts and lipid peroxidation

also inplammation from cirrhosis

oral cancer from poor hygiene
-alcohol met by flora to acetaldyhyde increasing DNA damage in high conc

Question 5

alcohol + tobacco

Answer 5

initiation and promotion

• initiation a and t
• promotion by alcohol causing growth

Question 6

exercise

Answer 6

strongest associated cancer decreaser