L5 - Pain Flashcards
What is phantom pain?
When amputees still feel pain in amputated limb
What is analgesia?
Incapability of feeling pain
What did Heinbecker do?
Took a heat stimulus to a hand
Recorded neurons in wrist
When heat actually got painful, nociceptor started firing a lot
What do A-d respond to?
Sharp pain
Mechanoreceptor
What to c fibres respond to?
Heat, pressure, noxious chemicals (ache feeling)
What is Na channel 1.7?
Has cell bodies in DRG
TTX blocks channel and get no current
Important in burning pain
What is erythromelalgia?
Experience a burning pain in their warm feet caused by a mutation
What mutation is in Na channel 1.7 to cause erythromelalgia?
F1449V
Opens channels so lots of pain stimuli
What mutation can give no pain?
W897X in Na 1.7
What does aspirin do?
Blocks cyclooxygenase making the prostaglandin in inflammatory soup
- Modifies Ser-530
What are NSAIDS and what are the two examples/
non steroidal anti inflammatory drugs
Ibuprofen
Paracetamol
What does ibuprofen do?
Inhibitor of cylooxygenase
What does paracetamol do?
COX-3 inhibitor
What does capsaicin do?
Activaties TRPV1 channels
What do capsaicin patches do?
Blocks creation of action potential
What happens in the substantia gelatinosa?
Sensory neurons come in through top and make connections and go down to dorsal horn
anatomically arranged
What are enkephalins sometimes called?
endogenous opioids
What does morphine do?
Analgesic in spinal cord
What are the features of Substance P?
11 aa peptide
Found in CNS and dorsal horn
example of a tachykinin
What does capsaicin block?
C fibres
What is TENS?
Stimulates large fibres dealing with pain
What are another category of pain modulators?
SSRIs and SNRIs as analgesics
Seretonin and adrenaline stay around
What part of the brain has nocioceptors?
meninges only
What part of the brain is to do with emotions and pain?
Anterior cingulate cortex (ACC)
What does the ACC require?
LTP
