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Brain in Health & Disease > L5 - Pain > Flashcards

L5 - Pain Flashcards

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1
Q

What is phantom pain?

A

When amputees still feel pain in amputated limb

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2
Q

What is analgesia?

A

Incapability of feeling pain

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3
Q

What did Heinbecker do?

A

Took a heat stimulus to a hand
Recorded neurons in wrist
When heat actually got painful, nociceptor started firing a lot

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4
Q

What do A-d respond to?

A

Sharp pain

Mechanoreceptor

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5
Q

What to c fibres respond to?

A

Heat, pressure, noxious chemicals (ache feeling)

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6
Q

What is Na channel 1.7?

A

Has cell bodies in DRG
TTX blocks channel and get no current
Important in burning pain

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7
Q

What is erythromelalgia?

A

Experience a burning pain in their warm feet caused by a mutation

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8
Q

What mutation is in Na channel 1.7 to cause erythromelalgia?

A

F1449V

Opens channels so lots of pain stimuli

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9
Q

What mutation can give no pain?

A

W897X in Na 1.7

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10
Q

What does aspirin do?

A

Blocks cyclooxygenase making the prostaglandin in inflammatory soup
- Modifies Ser-530

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11
Q

What are NSAIDS and what are the two examples/

A

non steroidal anti inflammatory drugs
Ibuprofen
Paracetamol

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12
Q

What does ibuprofen do?

A

Inhibitor of cylooxygenase

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13
Q

What does paracetamol do?

A

COX-3 inhibitor

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14
Q

What does capsaicin do?

A

Activaties TRPV1 channels

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15
Q

What do capsaicin patches do?

A

Blocks creation of action potential

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16
Q

What happens in the substantia gelatinosa?

A

Sensory neurons come in through top and make connections and go down to dorsal horn
anatomically arranged

17
Q

What are enkephalins sometimes called?

A

endogenous opioids

18
Q

What does morphine do?

A

Analgesic in spinal cord

19
Q

What are the features of Substance P?

A

11 aa peptide
Found in CNS and dorsal horn
example of a tachykinin

20
Q

What does capsaicin block?

A

C fibres

21
Q

What is TENS?

A

Stimulates large fibres dealing with pain

22
Q

What are another category of pain modulators?

A

SSRIs and SNRIs as analgesics

Seretonin and adrenaline stay around

23
Q

What part of the brain has nocioceptors?

A

meninges only

24
Q

What part of the brain is to do with emotions and pain?

A

Anterior cingulate cortex (ACC)

25
Q

What does the ACC require?

A

LTP

Brain in Health & Disease (9 decks)

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