L5 - gut organoids / Wnt signalling Flashcards
1
Q
outline the mammalian gut crypt
A
located at the base of the villi
tube of cells with stem like cells in a niche at the distal end and differentiating cells at the proximal end
2
Q
where is the mammalian gut located
A
tube of cells arranged on the basolateral membrane
3
Q
what are transit amplifying cells
A
mammalian gut crypt stem cell progeny that move upwards and differentiate
4
Q
what do the mesenchymal cells in the mammalian gut crypt do
A
send signals that help regulate stem cell activity
5
Q
what are the cells in the mammalian gut than respond to Wnt signals
A
CBC - they express Wnt target genes and end up being the stem cell
