L5 Clearance Concepts

Question 1

What is an assumption for us to come up with the CLb = Q X E equation?

Answer 1

We assume distribution is instantaneous, (we can assume this as liver and kidney is highly perfused)

Question 2

drugs with intermediate E are influenced by?

Answer 2

elimination efficiency (E) e.g. fu and CLint,
AND blood flow (Q)

Question 3

how can we find plasma clearance (CL)?

Answer 3

Dose/AUC (IV) or F x Dose/AUC (ev)

Question 4

are V and CL dependent on half live (t 1/2)?

Answer 4

No, V is related to plasma and tissue protein binding and CL is related to its ability to clear a drug