L4 - receptors Flashcards
list the (3) locations receptors can be located, and give examples for each
plasma membrane
-LGIC, GPCR, intrinsic enzymes
Intracellular receptors (on organnelle membranes, eg mitochondria or vesicles)
- Ryanodine receptors
- VMAT
- IP3
Nuclear receptors (which interact with DNA) - Steroid receptors
list the 4 functional types of receptors
LGIC
GPCR
intrinsic enzymes
Nuclear receptors
briefly desrcibe the basic fucntion of Ryanodine and IP3 receptors
LGIC that allow Ca2+ entry
give examples of nuclear receptors (DNA binding receptors)
oestrogen receptor
retinoic acid receptor
steroid receptors
describe structure of Nuclear receptors
LBS on the C terminal
dimerisation domain on the N terminus
between the dimerisation domain and the LBS there are zinc fingers
what is the importance of the dimerisation domain on nuclear receptors
receptors exist as monomers but dimerise with another ligand-bound receptor to become activated before entering the nucleus
describe the mechanism of nuclear receptor activation
- ligand binding to receptor activates it, but it must dimerise with another activated receptor before it can enter the nucleus
- after dimerisation the receptor can cross into nucleus and can alter expression of genes
- alters mRNA expression and so alters protein synthesis
where are intracellular membrane receptors found in neurones?
ER memrbane
describe ryanodine receptor
ligand gated calcium channel -> activated by Ca2+ (and some other ligands)
causes Ca2+ release from ER or SR (Ca2+ activated calcium release)
describe IP3 receptor
ligand gated Ca2+ channel - activated by 2nd messenger inositol 1,4,5 triphosphate (IP3)
causes Ca2+ release form ER or SR
where are IP3 and ryanodine receptors located?
membranes of SR or ER
list the types of plasma membrane receptors
LGIC
GPCR
intrinsic enzyme receptors
what are the 3 main types of LGIC families
Nicotinic receptor like
ATP receptors (P2X)
Ionotropic glutamate receptors
gove examples of Nicotinic R like ion channels
NAChR 5-HT3 GABA(A) Glycine ZAC (zinc activated)
how many types of P2x receptor are there
7