L3 : Protein CoAlation and Antioxidant Function Flashcards by Fish San

Q

How is CoA synthesised?

A

Enzymatic conjugation of cysteine, panthothenate (vitamin B5) and adenosine
Requires ATP

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Q

What are the cellular functions of CoA?

A

Fatty acid synthesis
Cholesterol/ketones synthesis
Neurotransmitter synthesis
ATP biosynthesis
AA metabolism
Protein acetylation

Protein CoAlation (only induced in oxidative and metabolic stress responses)

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Q

What are cellular functions of protein CoAlation?

A

Modulation of activity
Subcellular localisation
Protection from overoxidation
Regulatory interactions
Changes in conformation

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