L3 cardio Flashcards
Cardiovascular System function
– Primarily TRANSPORT for cellular respiration
– Mediated by perfusion of ~ 40 billion capillaries
– Supply cells with O2 and nutrients
– Removes waste (Inc. CO2)
– Heat regulation
– Endocrine hormonal transport
– Immune function supply
– Regulation of blood volume

what is cardiovascular system composed of :
- heart
- pumonary circulation (low pressure system ~ 25mmHg)
– systemic circulation (high pressure system ~ 120mmHg)
Supplies cells with nutrients + O2, matches demand
output of pulmonary go to the input of systemic
circulatory system
The heart pumps blood through two separate circulatory systems:
– systemic circulation (LH to body) – pulmonary system (RH to lungs)
Both systems are interconnected so a problem with blood flow in one affects the other.
Blood always moves in one direction (RH to pulmonary circulation to LH to systemic circulation and back to RH)
structure of heart

heart anatomy

heart wall layers, functions, pathology

myocardium: structure, function and pathology

Myocarditis
– RARE infection to the myocardium
– Inflammatory substances infiltrate the heart muscle causing thickening, or, heart gets dilated and floppy.
– This interferes with filling and pumping… Causes catastrophic drop in blood pressure
– Often occurs in young, previously healthy people
– Usually requires heart transplant
Myocardial hypertrophy
It will develop to some degree through aerobic training
As a disease process develops
– from long standing high blood pressure
– The thickened muscle wall makes it difficult for the heart chambers to fill and muscle contraction becomes less effective
– The conductions system runs through the muscle layers and gets ‘messed up’ causing rhythm problems
endocardium
– epithelial tissue that lines entire vasculature
– thin layer continuous with endothelium of arteries, veins, and capillaries
– prone to infection

Anatomy of the Heart Wall

valve of the heart
AV (atrioventricular) – prevent blood entering atria from ventricle during systole
– TRICUSPID: Right Atrium + Right Ventricle
– MITRAL: Left Atrium + Left Ventricle
SEMILUNAR – prevent blood entering ventricle from arterial (pulmonary + aorta) tree during diastole
– AORTIC: Left Ventricle + Aorta
– PULMONARY: Right Ventricle + Pulmonary Artery
valve of the heart structure

valve regurgitation
– Blood flows back and forth across valve
– Blood flow from the heart reduced
– Poor cardiac output
valve stenosis
– Blood trying to squeeze through narrow valve opening
– Blood flow from the heart reduced
– Poor cardiac output
– ?poor coronary artery filling
valve pathology

Coronary circulation
– The heart is a “hungry beast” – high oxygen requirements
– Myocardial O2 consumption > skeletal muscle – (65% extracted vs 25%)
– Left and right coronary arteries
– increase myocardial metabolic demand = increase coronary blood flow – Local response not ANS
Blood Vessels associated with the Heart
Vessels returning blood to the heart include:
– Superior and inferior
venae cavae
– Right and left pulmonary veins
Vessels conveying blood away from the heart:
– Pulmonary trunk, which splits into right and left pulmonary arteries
– Ascending aorta

vasclature layers
Tunica intima: endothelium, single layer of flattened cells
Tunica intermedia: smooth muscle and elastic tissue regulated by sympathetic nervous system: controls vessel constriction and dilation
Tunica adventitia: fibrous connective tissue and collagen

Cardiac Output
HRXSV=CO
– Cardiac output is the amount of blood pumped by each ventricle in one minute
– Cardiac output is the product of heart rate (HR) and stroke volume (SV)
– Heart rate is the number of heart beats per minute
– Stroke volume is the amount of blood pumped out by a ventricle with each beat
determinants of CO
– Preload – amount ventricles are stretched by contained blood
– Afterload – resistance against which the ventricles have to overcome to eject blood into the large arteries
– Contractility – cardiac cell contractile force e Calcium ions, actin & myosin binding
preload
– Volume of blood that fills the ventricles during diastole
– Influenced by total blood volume
– The greater the venous return, the more the myocardial fibres will stretch
– Frank Starling’s Law – “the greater the myocardial stretch, the greater the force of contraction”
– Preload increased in systolic heart failure – (because blood backs up in the pulmonary system)
– Preload decreased in hypovolaemia
afterload
Afterload
– Afterload - Resistance to ventricular ejection
– Load the ventricle must move during contraction
– Controlled by the sympathetic nervous system
– increase Resistance to flow in systemic circulation (SVR)
– Hypertension
– vasoconstriction
– Aortic & pulmonary valve stenosis
– Increased blood viscosity
– Disease
– eg Atherosclerosis
– Coarctation of aorta
– Reduced by hypotension & vasodilation
Contractility
– Ability of myocardium to contract when no change in preload or afterload
– Contractility determines force of contraction which determines SV
– 2 factors influence force of contractility:
(i) changes in stretching of myocardium caused by changes in preload
(ii) alterations in SNS
– β adrenergic receptors are stimulated by noradrenaline – circulating adrenaline
– Altered by hypoxaemia

















