L2- Cell cycle mitosis, their regulation Flashcards

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1
Q

Cell cycle

A

prokaryotic cells- cell cycle occurs via a process termed binary fission.
eukaryotic cells, the cell cycle can be divided in two periods- a) interphase b) mitosis

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2
Q

Interphase

A
G1 phase:-
Growing
Synthesize new proteins and organelles
Doing their jobs
Longest phase of cell cycle

S Phase
Chromosomes(DNA) are replicated
Key proteins associated with replication are made (centromeres)

G2 Phase
Shortest of the 3 phases of interphase
Organelles and molecules for cell division are produced (centrioles)
Check-up phase before mitosis.

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3
Q

Checkpoints

A

A checkpoint in the cell cycle is a critical control point where stop and go signals regulate the cycle.

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4
Q

cell cycle regulators

A

Protein kinases

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5
Q

Internal Regulators

A

Cdk
MPF
p53
p27

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6
Q

Cdk

A

Adds phosphate to a protein
major control switches for the cell cycle
to move the cell from g1 to s and s to g2

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7
Q

MPF

A

Cdk and cyclin that triggers progression through the cell cycle.

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8
Q

p53

A

protein that blocks the cell cycle if dna is damaged

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9
Q

p27

A

protein that binds to cyclin and cdk to block entry into s phase.

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10
Q

Endogenous hormones

A

Auxin, cytokinins, abscisic acid, gibberellins and brassinosteroids.

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11
Q

Interphase

A

chromosomes are extended form and seen as chromatin.

Nucleus is visible

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12
Q

Prophase

A

nucleus and nuclear envelope break down
chromatin condenses into chromosomes
spindle fibres grow from centrioles
centrioles migrate to opposite poles

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13
Q

Metaphase

A

chromosomes align at the center
spindle fibers are attached
nuclear membrane has disappeared

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14
Q

Anaphase

A

centromere split and sister chromatid are pulled to poles

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15
Q

Telophase

A

chromosomes again become longer and thin
new nuclear membrane formed
cell division almost complete

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