L19-Control of bladder emptying Flashcards
1
Q
What is a typical maximum volume for the bladder?
A
500-1000ml
2
Q
What does the wall of the urinary bladder consist of?
A
Urothelium
Lamina propria
Detrusor smooth muscle
Serosa
3
Q
What are the special cells lining the urinary side of the urothelium called?
A
Umbrella cells, they can relay signals to lamina propria on contents of urine
4
Q
What is contained within the lamina propria?
A
A mesh of sensory neurones contained within the connective tissue allows mechanical and chemical signals to be relayed.
5
Q
What signal causes detrusor muscle to contract?
A
Parasympathetic Ach acting on M3 receptors
6
Q
How is an overactive bladder managed pharmocologically?
A
antimuscarinic drugs but develop tolerance to them.
B3 adrenoceptor agonists
