L18- anti cancer drugs Flashcards
1
Q
why is mustard gas toxci
A
-toxic to normal cells esp WBCs
2
Q
how is mustard gas useful in terms of cancer
A
- can be optimised to kill off cancer cells
3
Q
types of chemo
A
- adjuvant - reduces the risk of recurrence of cancer after the cancer is gone
- neo-adjuvant- reduces the size of the tumour so it’s easier to remove it surgically as well as getting rid of any leftover cancer cells
- palliative - improving quality of life and the lifetime
4
Q
why use chemo with surgery
A
produces most efficient results
5
Q
use of chemo
A
- curative-
- palliative
6
Q
types of chemo drugs
A
cell cycle specific
-cell cycle non specific
7
Q
types of cytotoxic drugs used in chemo
A
- alkylating agents
- platinum agents
8
Q
what are alkylating agents
A
alkyl groups moved to the DNA based and two bases are alkylated to form cross bridges
- prevents DNA from being seperated for DNA synthesis
- not cell cycle specific cos it binds to all DNA
9
Q
cytotoxic effects of alkyating agents
A
-have an effect on DNA, inducing apoptosis
-
10
Q
what are platinum agents
A
bind CV to purine DN bases
-prevents DNA separating
11
Q
what are anti metabolties
A
interfere with incoparatirion of nucelic acids
-s phase specific
