L13: Neurodevelopment

Question 1

What are the 3 germ layers in the primary germ cell, and what do they produce?

Answer 1

Ectoderm: CNS, Skin

Mesoderm: Muscle, bone, kidneys, blood

Endoderm: Lining of gut, liver, lungs.

Question 2

WhT is the development pathways for SVZ cells?

Answer 2

1: Neural stem cells (type B)-> Transit amplifying cells (type c)-> Migrating fibroblast(type A)-> Migration
2: Neural stem cell (B)-> Transit amplifying cells (C)->Immature Neurons (A) -> Migration

Question 3

What about the hippocampus?

Answer 3

NSC in the subgranular zone> Progenitor cell > Immature neutron> Migration into granule cell layer > integration

Question 4

Cellular and molecular elements of the stem cell niche?

Answer 4

Astrocytes, endothelial cells, ependymal cells

Molecular signals- VEGF,FGF,EGF,BDNF,SHH