L12: Nerve injuries in the lower limb Flashcards
Describe the basic structure of a neurone?
Dendrites--> thin structures arising from the cell body Cell body--> Collates information Axon hillock--> origin of axon Axon--> specialised cellular extension Synaptic knob--> synapses
Describe the basic structure of a nerve?
Bundle of axons and supporting cells
Axon surrounded by endoneurium (glucocalyx and mesh of collagen)
Bundle of axons–> fascicles
Fascicle surrounded by perineurium
Fascicles grouped and surrounded by epineurium
Own blood supply–> vasa nervorum
What is the endoneurium?
Glycocalyx and mesh of collagen
Surrounded by endoneurial fluid
Similar to blood brain barrier and CSF
What is the Seddon classification?
Way of classifying nerve injuries
What are the different classes in the Seddon classification?
Class I: Neurapraxia
Class II: Axonotmesis
Class III: Neurotmesis
What is Neurapraxia?
Mildest type Temporary physiological block of conduction of the affected neuron- No conduction across damaged area- Proximal and distal normal Endo-, Peri- and epineurium all in tact No Wallerian degeneration Sensory and motor loss distal to injury Full recovery--> Period of days to weeks
What is Axonotmesis?
Loss of continuity of axon and myelin sheath
Endo-, Peri and epineurium are preserved
Wallerian degeneration–> 24-36 hours –> distally
Axonal regeneration–> full recovery without surgery
Axon regeneration proceeds at 1-3mm/day–> time of recovery depends on distance from site of injury
What is Neurotmesis?
Partial or complete division of axons, endo-, peri- and epineurium
Wallerian degeneration –> sensory, motor and autonomic defects severe
Surgical intervention always required
Deposition of scar tissue prevents regeneration
What is Wallerian degeneration?
Axon distal to injury degenerates–> antegrade or orthograde degeneration (away from cells body)
Starts within 24-36 hours
Prior to degeneration–> distal axon stump is electrically excitable
Describe the process of Wallerian degeneration?
- After injury–> axon skeleton disintegrates, and axonal membrane breaks apart
- Followed by degeneration of myelin sheath and infiltration by macrophages
- Macrophages and Schwann cells phagocytose debris–> 10-14 days
- Within 3 days Schwann cells begin regeneration–> 3 weeks formed ‘Bands of Bunger’–> guide axon regeneration –> denervated muscle atrophys
- Axon regeneration successful–> muscle innervated-> muscle regeneration
What happens if regeneration is unsuccessful?
If ends not surgically reopposed, ineffective, unregulated regeneration of axons occurs
Sprouting of axon–> traumatic neuroma forms
Painful
Reinnervation does not occur–> muscle replaced by fibrous tissue and fat
What are some of the other causes of neuropathy?
Traction (stretch)
Extrinsic pressure–> tumour, abscess, displaced fracture
Medical conditions–> diabetes, alcohol excess and drugs
Tumours of nerves–> Neurofibromas, acoustic neuroma (vestibulocochlear nerve)
What is a prolapsed intervertebral disc?
Commonly called a slipped disc
IVD pushes out of place
What are the most common sites for nerve root injuries caused by a prolapsed IVD? Why?
L4/5 and L5/S1
Due to mechanical loading at these joints
In the lumbar and sacral region of the spine how do the nerve roots exit?
Emerge below the respective vertebrae–> L4 exits in L4/5 Intervertebral foramen
What is the nerve root that exits at the level called? What is the nerve root that exits below called?
Exiting nerve root–> exits at same level
Traversing nerve root–> emerges at level below
In the lumbar spine which nerve root is normally damaged by a paracentral herniation?
Traversing nerve root
What is the root value of the sciatic nerve? Which muscles does it innervate?
L4, L5, S1, S2, S3
Hamsting muscles–> Biceps femoris, Semimembranosus, Semitendinosus
Adductor magnus (hamstring portion)
Still single sciatic nerve but common peroneal component innervates the short head of biceps femoris, other hamstring innervated by tibial
portion
Branches at popliteal fossa–> Tibial (posterior compartment) and Common peroneal (superficial- lateral, deep- anterior)
Also innervates muscles of the leg and foot
What is the cutaneous supply of the sciatic nerve?
Innervates skin of
Common peroneal - proximal lateral leg (anterior)
-Superficial peroneal (fibular) nerve- Distal lateral leg and dorsum of foot
- Deep peroneal (fibular) nerve- Between great toe and next toe!
Tibial nerve - Heel of foot (posterior)
–> Medial plantar–> medial sole of foot up to medial 3.5 toes
–> Lateral plantar–> Lateral sole of foot and lateral 1.5 toes
Sural nerve- posterior distal lateral leg (ankle) and lateral side of foot and little toe
(posterior)
What is the normal course of the sciatic nerve from the pelvis to the leg?
- Exits via the greater sciatic foramen (going posteriorly)
- Anterior and inferior to piriformis
- Posterior surface of short external rotators (superior gemellus, obturator internus, inferior gemellus and quadratus femoris)
- Enters posterior thigh–> deep to long had of biceps femoris (between biceps femoris and adductor magnus)
- Bifucates into tibial and common peroneal at apex of popliteal fossa