L12: glysolysis Flashcards
what are the 2 metabolic pathways
anabolic
catabolic (hydrolysis & oxidation)
what is an anabolic pathway?
use energy to synthesize complex molecules
endergonic
molecular order: increase
entropy: decrease
what are the 2 types of catabolic pathway
aerobic (with oxygen)
anaerobic (without oxygen)
exergonic
molecular order: decrease
entropy: increase
how do cells store chemical energy?
atp
gtp
acetyl coa
creatine phosphate
reduced coenzymes to increase reduction potential
what is hydrolysis
a bond that is broken by an addition of water
why is atp the most convenient energy currency for the cell?
7.3 kcal/mol
most reactions require energy level around ATP-wasting less than using other higher molecules
what is oxidation
exergonic
dehydrogenation: H+ is removed
ex. ethanol -> acetaldehyde
what is reduction
endergonic
hydrogenation: H+ is added
ex. acetaldehyde -> ethanol
NAD
nicotinamide (b vitamin niacin) adenine dinucleotide
reduced form: NADH (acceptor of electrons)
oxidized form: NAD+ (donor of electrons)
-coenzymes in oxidoreductase
Phosphorolytic cleavage
similar to hydrolysis, but uses inorganic phosphate to break the bond rather than h20
-Pi breaks the down between glucose units
ex. glucose-1-phosphate -> glucose-6-phosphate (metabolized in the glycolytic pathway)
OIL RIG
oxidation is losing, reduction is gaining
glycolytic pathway review
location: cytosol
phase 1: preparation and cleavage
phase 2: oxidation and atp generation
phase 3: pyruvate formation and atp generation
phase 1: preparation and cleavage
glucose (6 OOOOOO)—-> 2 molecules of glyceraldehyde-3-phosphate ( 3 OOO & 3 OOO)
2atp–> 2 adp
phase 2: oxidation and atp generation
2 molecules of glyceraldehyde-3-phosphate (3 OOO & 3 OOO) —-> 2 molecules of 2 molecules of 3-phosphoglycerate (3 OOO & 3 OOO)
2 adp & pi –> 2 atp
2 NAD+ –> 2 NADH (oxidized)
phase 3: pyruvate formation and ATP generation
2 molecules of 3 phosphoglycerate (3 OOO & 3OOO) —-> 2 molecules of pyvurate ( OOO & OOO)
2 adp & pi–> 2 atp (synthesis)