L10_Treating Chronic Inflammatory Illness Flashcards
1
Q
Describe the differences in COX-1 & COX-2 expression.
A
- cox-1 is constitutively expressed in the body.
- cox-2 is related to a stimulus e.g. inflammation or infection.
- cox-2 is more likely to be produced in some cells (macrophages) compared to others.
2
Q
Name two non-selective COX inhibitors.
A
- ibuprofen & aspirin.
3
Q
What is the half-life of paracetamol?
A
- 2 h.
4
Q
What is the MoA of methotrexate?
A
- inhibits DNA, therefore attenuating RNA synthesis of proteins.
5
Q
Why should patients taking methotrexate take folate supplements intermittently?
A
- bc methotrexate is a folate competitor.
6
Q
Which disease is hydroxychloroquine prescribed for?
A
- malaria.
7
Q
What is the MoA of hydroxychloroquine?
A
- it increases the lysosomal pH in macrophages and other APCs.
- there will be less breakdown of the antigens, leading to less presentation of the antigens to the T-helper cells.
8
Q
What medication can be given for RA for pain, stiffness and swelling?
A
- NSAIDs or steroids.
9
Q
DMARDs are given in the treatment of RA. Why are they prescribed early?
A
- bc they take months (3) to take effect.
10
Q
What is the first-line treatment for RA?
A
- methotrexate with folic acid.
