L1 - the nature of cancer Flashcards
1
Q
What is a hallmark of cancer?
A
An element that is characteristic of all cancers
2
Q
What are the hallmarks of cancer?
A
- Sustained proliferative signalling
- evading growth suppressors
- activating invasion and metastasis
- avoiding immune destruction
- enabling replicative immortality
- genome instability and mutation
- inducing angiogenesis
- resisting cell death
3
Q
What is the biggest risk factor assigned to cancer?
A
AGE
4
Q
Do all populations show the same frequency of cancer?
A
No - Japanese migration study
5
Q
Is there a genetic basis for cancer?
A
Yes, some families show susceptibility to certain cancers implying existence of tumour suppressor genes
6
Q
Give an example of an assignable influence
A
Snuff, chimney sweep, smoking!!
7
Q
What is the difference between a nude mouse and an oncomouse
A
A nude mouse is immunocompromised and able to accept non-self cells in order to study human cancers. The oncomouse has been genetically manipulated in order to study the formation of mouse cancers within the mouse model.
