L1-LEUKOCYTES Flashcards
refers to the movement of cells through developmental stages, into the circulation, and from the circulation to the tissues and includes
the time spent in each phase of the cell’s life.
KINETICS
2 FORMS OF NEUTROPHIL:
BAND ANG SEGMENTED NEUTROPHILS
Make up the vast majority of circulating leukocytes
SGEMENTED NEUTROOPHILS
Common progenitor of neutrophil:
GRANULOCYTE-MONOCYTE PROGENITOR
What is the major cytokine responsible for the stimulation of neutrophil production?
GRANULOCYTE COLONY-STIMULATING FACTOR (G-CSF)
3 POOLS OF DEVELOPING NEUTROPHIL IN BM:
Stem cell, Proliferation and Maturation Pool
This consists of HEMATOPOIETIC STEM CELLS (HSCs) capable of SELF-RENEWAL and differentiation.
STEM CELL POOL
Consists of DIVIDING CELLS and includes COMMON MYELOID PROGENITORS, ERYTHROCYTE, MONOCYTE, & MEGAKARYOCYTE (CFU-GEMMs); GRANULOCYTE-MACROPHAGE PROGENITORS; MYELOBLAST; PROMYRLOCYTES & MYELOCYTES.
PROLIFERATION POOL
consisting of cells undergoing nuclear maturation that form the marrow reserve and are available for release: METAMYELOCYTES, BAND NEUTROPHILS, AND SEGMENTED NEUTROPHILS
MATURATION POOL