L1: Homeostasis & autonomic nervous system Flashcards

1
Q

What does homeostasis encapsulate?

A

-Control of the internal environment
-Maintenance of equilibrium
-Maintenance of variables within limited ranges
-Involves integrated function of different organ systems

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2
Q

What happens is homeostasis is not maintained?

A

It results in disease (pathophysiology)

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3
Q

Where are changes in light detected in the eye?

A

Via the ganglia within the retina

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4
Q

What are the different physiological control mechanisms?

A

Nervous system (ANS or SNS)
Endocrine system (hormones)
Paracrine systems (local control)

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5
Q

What is one of the major functions of the ANS?

A

To maintain homeostasis

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6
Q

Which nerve fibres control the ANS?

A

Sensory afferent nerve fibres

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7
Q

What are the control centres of the ANS?

A

Hypothalamus
Brain stem
Spinal cord

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8
Q

What are the efferent pathways of the ANS?

A

Sympathetic nervous system and parasympathetic nervous system

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9
Q

What are common features of the efferent pathways of the ANS?

A

2 neurons in series
Preganglionic neurones (start in CNS)
Postganglionic neurones (start in autonomic ganglia)
1 preganglionic : many postganglionic

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10
Q

What bone compound may have been found to have an important role in fight or flight?

A

Osteocalcin

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11
Q

What is the preganglionic origin of the parasympathetic nervous system?

A

Cranial nerve:
III (oculomotor) - eye
VII (facial) - lacrimal, nasal and submandibular
IX (glossopharyngeal) - parotid
X (vagus) - thorax, 2/3 abdomen
Pelvic nerve: rectum & bladder

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12
Q

What is the postganglionic origin of the parasympathetic nervous system?

A

Ganglia on or near target organ

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13
Q

What are the sizes of the pre and postganglionic nerves in the parasympathetic nervous system?

A

Pre: long
Post: short

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14
Q

Where is the preganglionic origin of the sympathetic nervous system?

A

Thoracic 1 (T1) to Lumbar 2/3 (L2/3)

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15
Q

What is the postganglionic origin of the sympathetic nervous system?

A

2 Paravertebral sympathetic chains

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16
Q

What are the sizes of the pre and postganglionic neurons in the sympathetic nervous system?

A

Preganglionic: short
Postganglionic: long

17
Q

What is an exception of the sympathetic nervous system?

A

It controls the adrenal medulla

18
Q

How does the sympathetic nervous system control the adrenal medulla?

A

It directly links the CNS and adrenal medulla using a preganglionic neurone for adrenaline & noradrenaline secretion into the bloodstream

19
Q

What are the main NTs produced by the ANS?

A

Acetylcholine (Ach)
Noradrenaline (NAdr)
Adrenaline (Adr)
Non-adrenergic + non-cholinergic (NANC) NTs

20
Q

What type of synapses does the ANS have?

A

Cholinergic- nicotinic and muscarinic
Adrenergic - alpha or beta

21
Q

What are the main components of nicotinic receptors?

A

They have ganglia in the SNS and PNS
Usually involved in the NMJ

22
Q

What are nicotinic receptors blocked by?

A

Curare

23
Q

What are components of muscarinic receptors?

A

Target organ in PNS (although there are exceptions)

24
Q

What are muscarinic receptors blocked by?

A

Atropine (deadly nightshade)

25
Q

What are components of the Alpha 1&2 adrenoceptors?

A

Alpha 1 - postsynaptic
NAdr>Adr
Vasoconstriction and smooth muscle contraction
Alpha 2 - presynaptic
NAdr>Adr
Reduction in adrenergic and cholinergic transmission
Both blocked by phentolamine

26
Q

What are components of the Beta 1&2 adrenoreceptors?

A

Beta 1 - Heart
Adr=NAdr
Increase heart rate and force of contraction
Beta 2
Adr>NAdr
Vasodilation and smooth muscle relaxation
Both blocked by propranolol