L1: Absorbtion and Distribution of Drugs Flashcards
Where should the medicine be introduced to have quick effect?
intravenous route.
What is pharmacodynamics?
It is what the drug does to the body.
What is pharmacokinetics?
It is what the body does to the drug.
What does pharmacokinetics include?
Absorbtion
Distribution
Metabolism
Execration
What is elimination?
Metabolism + excretion
Why is there some lag in the start of the curve of the time course of drug action (oral)?
Due to Absorption but in intravenous, there is no lag.
Where should the drug concentration be kept?
In the therapeutic window.
What is absorption?
Absorption is defined as the passage of a drug from the site of administration to plasma.
What are the main routes of administration of drugs?
- Sublingual.
- Oral
- Rectal.
- Local.
- Inhalation.
- Injections.
Does the sublingual route have any Barriers?
No
What are the internal routes of administration?
- Sublingual.
- Oral
- Rectal.
What are the external routes of administration of drugs?
- Local.
- Inhalation.
- Injections.
What are the factors that affect the rate of Absorption?
A. Factors related to the drug:
• Ionization of the drug (pKa)
B. Factors related to the absorbing surface:
• Rate of the circulation at the site of absorption.
What is the ionization constant (pKa)?
It is the pH at which the ionized and non-ionized forms of the drug are equal.
Are ionized forms lipid soluble or no?
Unionized forms are more lipid-soluble and rapidly absorbed.