L09 - Contraception & HRT Flashcards
Which contraceptive methods have the potential for user failure and which do not?
- Methods without user failure = IUD, IUS, implant, sterilisation
- Methods with user failure = barrier, hormonal, natural family planning & lactational amenorrhoea
List 2 barrier methods other than condoms.
How are they used?
1 - Diaphragms
2 - Caps
- They are inserted into the cervix and used in combination with spermicides
What is a LARC?
What are the advantages of LARCs?
- Long-acting reversible contraception - a method that requires administration less than once per cycle/month
1 - Effectiveness doesn’t depend on memory or use
2 - More effective than other forms of contraception
3 - Cost-effective
What are intrauterine systems?
Describe the mechanism of action of intrauterine systems.
- Intrauterine systems are small, plastic T-shaped devices that are inserted into the uterus
- They gradually release levonorgestrel, a progesterone analogue. This causes:
1 - Thinning of the endometrium
2 - Thickening of the cervical mucus
3 - Inhibition of ovulation by negative feedback of FSH and LH
What are intrauterine devices?
Describe the mechanism of action of intrauterine devices.
- Intrauterine devices are small, plastic T-shaped devices with copper on the stem / arms that are inserted into the uterus
- They are directly toxic to both the sperm and the egg
- If fertilisation occurs, they prevent implantation by inducing a foreign body reaction
What are the advantages and disadvantages of intrauterine systems?
- Advantages: reduces menstrual bleeding / may induce amenorrhoea, reduced dysmenorrhoea, may reduce pain from endometriosis or adenomyosis
- Disadvantages: pelvic exam & speculum to insert, hormonal s/e (headache, breast tenderness, acne), irregular bleeding (up to 9 months), benign ovarian cysts, no STI protection, expulsion <1:20
What are the advantages and disadvantages of intrauterine devices?
- Advantages: effective immediately, use as emergency contraception, non-hormonal
- Disadvantages: pelvic exam & speculum to fit, may increase menstrual blood loss, may worsen dysmenorrhoea, no STI protection, expulsion <1:20
What are the contraindications of intrauterine systems?
Pregnancy, >48hr or <4wk post-partum, post-partum sepsis, PID, gestational trophoblastic disease, cervical cancer, symptomatic STI cervicitis, pelvic TB, cardiac arrhythmias
What are the contraindications of intrauterine devices?
Pregnancy, >48hr or <4wk post-partum, post-partum sepsis, PID, gestational trophoblastic disease, cervical cancer, symptomatic STI cervicitis, pelvic TB, cardiac arrhythmias, copper allergy, valvular heart disease
Describe the mechanism of action of implants.
They release etonogestrel, a progesterone analogue, to:
1 - Prevent ovulation by negative feedback of FSH and LH
2 - Thicken cervical mucus
What are the advantages and disadvantages of implants?
- Advantages: highly effective, independent of intercourse, reduce HMB & dysmenorrhoea (may cause amenorrhoea), immediate return of fertility, may reduce risk endometrial cancer
- Disadvantages: fitting & removal procedure, irregular bleeding, hormonal (headache, breast tenderness, mood changes), affected by enzyme inducers, no STI protection
Describe the mechanism of action of injectable contraceptives.
- Contain progesterone
- Depo-Provera (150mg depo medoxy-progesterone acetate i.m. 12-14 weekly), Sayana Press (104mg s.c. 12-14 weekly), Norethisterone enanthate (200mg i.m. 8 weekly)
- Action: inhibit ovulation, thicken cervical mucus, thin endometrium
What are the advantages and disadvantages of injectable contraceptives?
- Advantages: highly effective, convenient, non-intercourse related, reversible, not affected by other medications, suitable for breastfeeding, reduces bleeding & pain, improved PMS, reduces severity of sickle cell crises in SCD
- Disadvantages: once given, can’t be removed, menstrual irregularities, weight gain, no STI protection, may delay fertility return (up to 1yr), hormone effects, decrease bone mineral density long term (returns after stopping)
Describe the mechanism of action of combined hormonal contraceptives.
- Contain oestrogen and progesterone
- Action: prevent ovulation (primary), thickens cervical mucus, endometrial thinning
What are the advantages and disadvantages of combined hormonal contraceptives?
- Advantages: regular, lighter, less painful periods, reduced risk ovarian/endometrial & colon cancer, may reduce premenstrual sx & improve acne
- Disadvantages: ↑ risk thrombosis, MI, stroke, HTN, breast cancer (reduces w/ time after stopping), cervical cancer (with longer use), affected by enzyme inducers