L09 - Contraception & HRT Flashcards

1
Q

Which contraceptive methods have the potential for user failure and which do not?

A
  • Methods without user failure = IUD, IUS, implant, sterilisation
  • Methods with user failure = barrier, hormonal, natural family planning & lactational amenorrhoea
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2
Q

List 2 barrier methods other than condoms.

How are they used?

A

1 - Diaphragms

2 - Caps

  • They are inserted into the cervix and used in combination with spermicides
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3
Q

What is a LARC?

What are the advantages of LARCs?

A
  • Long-acting reversible contraception - a method that requires administration less than once per cycle/month

1 - Effectiveness doesn’t depend on memory or use

2 - More effective than other forms of contraception

3 - Cost-effective

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4
Q

What are intrauterine systems?

Describe the mechanism of action of intrauterine systems.

A
  • Intrauterine systems are small, plastic T-shaped devices that are inserted into the uterus
  • They gradually release levonorgestrel, a progesterone analogue. This causes:

1 - Thinning of the endometrium

2 - Thickening of the cervical mucus

3 - Inhibition of ovulation by negative feedback of FSH and LH

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5
Q

What are intrauterine devices?

Describe the mechanism of action of intrauterine devices.

A
  • Intrauterine devices are small, plastic T-shaped devices with copper on the stem / arms that are inserted into the uterus
  • They are directly toxic to both the sperm and the egg
  • If fertilisation occurs, they prevent implantation by inducing a foreign body reaction
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6
Q

What are the advantages and disadvantages of intrauterine systems?

A
  • Advantages: reduces menstrual bleeding / may induce amenorrhoea, reduced dysmenorrhoea, may reduce pain from endometriosis or adenomyosis
  • Disadvantages: pelvic exam & speculum to insert, hormonal s/e (headache, breast tenderness, acne), irregular bleeding (up to 9 months), benign ovarian cysts, no STI protection, expulsion <1:20
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7
Q

What are the advantages and disadvantages of intrauterine devices?

A
  • Advantages: effective immediately, use as emergency contraception, non-hormonal
  • Disadvantages: pelvic exam & speculum to fit, may increase menstrual blood loss, may worsen dysmenorrhoea, no STI protection, expulsion <1:20
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8
Q

What are the contraindications of intrauterine systems?

A

Pregnancy, >48hr or <4wk post-partum, post-partum sepsis, PID, gestational trophoblastic disease, cervical cancer, symptomatic STI cervicitis, pelvic TB, cardiac arrhythmias

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9
Q

What are the contraindications of intrauterine devices?

A

Pregnancy, >48hr or <4wk post-partum, post-partum sepsis, PID, gestational trophoblastic disease, cervical cancer, symptomatic STI cervicitis, pelvic TB, cardiac arrhythmias, copper allergy, valvular heart disease

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10
Q

Describe the mechanism of action of implants.

A

They release etonogestrel, a progesterone analogue, to:

1 - Prevent ovulation by negative feedback of FSH and LH

2 - Thicken cervical mucus

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11
Q

What are the advantages and disadvantages of implants?

A
  • Advantages: highly effective, independent of intercourse, reduce HMB & dysmenorrhoea (may cause amenorrhoea), immediate return of fertility, may reduce risk endometrial cancer
  • Disadvantages: fitting & removal procedure, irregular bleeding, hormonal (headache, breast tenderness, mood changes), affected by enzyme inducers, no STI protection
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12
Q

Describe the mechanism of action of injectable contraceptives.

A
  • Contain progesterone
  • Depo-Provera (150mg depo medoxy-progesterone acetate i.m. 12-14 weekly), Sayana Press (104mg s.c. 12-14 weekly), Norethisterone enanthate (200mg i.m. 8 weekly)
  • Action: inhibit ovulation, thicken cervical mucus, thin endometrium
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13
Q

What are the advantages and disadvantages of injectable contraceptives?

A
  • Advantages: highly effective, convenient, non-intercourse related, reversible, not affected by other medications, suitable for breastfeeding, reduces bleeding & pain, improved PMS, reduces severity of sickle cell crises in SCD
  • Disadvantages: once given, can’t be removed, menstrual irregularities, weight gain, no STI protection, may delay fertility return (up to 1yr), hormone effects, decrease bone mineral density long term (returns after stopping)
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14
Q

Describe the mechanism of action of combined hormonal contraceptives.

A
  • Contain oestrogen and progesterone

- Action: prevent ovulation (primary), thickens cervical mucus, endometrial thinning

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15
Q

What are the advantages and disadvantages of combined hormonal contraceptives?

A
  • Advantages: regular, lighter, less painful periods, reduced risk ovarian/endometrial & colon cancer, may reduce premenstrual sx & improve acne
  • Disadvantages: ↑ risk thrombosis, MI, stroke, HTN, breast cancer (reduces w/ time after stopping), cervical cancer (with longer use), affected by enzyme inducers
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16
Q

What is the advantage of using a combined patch over combined pills?

A

Vomiting can affect pills, whereas combined patches are not affected by GI upsets

17
Q

Describe the mechanism of action of progestogen only pills.

A

Prevent ovulation (main action desogestrel POP), thicken cervical mucus, thin endometrium

18
Q

What are the advantages and disadvantages of progestogen only pills?

A
  • Advantages: effective, well-tolerated, reversible, less risk factors, can be used in breastfeeding & those that can’t use CHC, may improve PMS & reduce dysmenorrhoea & endometrial cancer risk
  • Disadvantages: menstrual irregularities, memory dependent, functional ovarian cysts, hormonal s/e (headaches, mood swings, depression, bloatedness, breast tenderness), no STI protection, ectopic risk if pregnancy occurs
19
Q

What are the contraindications of progestogen only pills?

A

Pregnancy, current breast cancer, decompensated liver disease & some malignant liver tumours, unexplained vaginal bleeding, undiagnosed breast conditions / past breast cancer, stroke, IHD, enzyme inducing drugs (rifampicin, griseofulvin, antiepileptics)

20
Q

What are the 3 main fertility indicators?

A

1 - Body temp

2 - Cervical secretions (mucus)

3 - Length of menstrual cycle

21
Q

What are the advantages and disadvantages of fertility awareness methods?

A
  • Advantages: awareness of fertility (avoid or plan for pregnancy), no physical s/e, avoids hormones/devices, acceptable to all faiths/cultures
  • Disadvantages: more reliable forms, may be considered messy/clinical, takes 3-6 cycles to learn effectively + daily records, time consuming, no STI protection, events (e.g. illness, stress or travel) may make indicators harder to interpret
22
Q

What are the criteria of the lactational amenorrhoea method?

A

For post-partum women:

  • Baby <6mths
  • Woman remains amenorrhoeic
  • Regular, exclusive breastfeeding
23
Q

How do male and female sterilisation methods work?

A
  • Male – vasectomy; permanent & irreversible on NHS; doesn’t affect sex drive or erections; ejaculation but no sperm; contraception for 8-12wks after so semen cleared; small infection risk
  • Female – tubal occlusion (Filshie clips or salpingectomy); permanent & irreversible on NHS; age not restriction
24
Q

What are the advantages and disadvantages of sterilisation?

A
  • Advantages: no need for further contraception, non-hormonal
  • Disadvantages: permanent, irreversible, higher failure rate than LARC
25
Q

What methods of emergency contraception are available?

A
  • Copper IUD = first line -> inserted up to 120hrs after first UPSI or within 5 days earliest expected ovulation; 99.9% efficacy; can be used for ongoing contraception or removed once pregnancy excluded
  • Levonorgestrel – efficacy up to 96hrs; 60% efficacy; can use multiple times per cycle; if vomiting within 2hrs, alternative method needed
  • Ulipristal acetate = EllaOne -> up to 120hrs after first UPSI / contraceptive failure; synthetic progesterone receptor modulator -> delays ovulation; prevents 60-80% expected pregnancies (significantly better than levonorgestrel); can be used multiple times per cycle