Kruse DSA Flashcards
what kind of anemia forms in iron deficiency
small erythrocytes with insufficient hemoglobin are formed
microcytic hypochromic anemia
what kind of iron is toxic
free inorganic iron
where is iron absorption occur
in duodenum and proximal jejunum
nonheme iron must be
reduced by ferrirefuctase to ferrous iron before absorption
heme iron in hemoglobin and myoglobin can be
absorbed intact without being dissociated into elemetnal iorn
(iron in meat protein)
when iron req are low and stores are high absorbed iron is diverted
into ferritin in intestinal epithelial mucosal cells for storage
increased erythropoiesis is associated with increase in what
number of transferrin receptors on developing erythroid cells
iron store depletion and iron deficiency anemia are associated with an increased concentration of
serum transferrin
which ferrous salts are used for oral iron therapy in iron deficiency anemia
ferrous sulfate, gluconate, fumarate
side effects of ferrous salts
nauseaepigastric discomfort abdom cramps constipation black stools diarrrhea
which pts require parenteral iron therapy
pts with advanced chronic renal disease requiring hemodialysis and treatement with erythropoeitin
small bowel resection
IBD involving the proximal small bowel, or malabsroption syndromes
iron forms parenteraly
iron dextran
sodium ferric gluconate complex and iron sucrose complex
iron dextran administered how
deep im injection or by iv infusion (more common)
iron dextran AE
headache light headedness fever arthralgias nausea vomiting back pain flushing urticaria bronchospamsm anaphlaxis death
sodium ferric gluconate complex and iron sucrose complex administered and AE
IV
less likely to cause hypersensitivity reactions
