Kruse 2 Flashcards
1
Q
NMJ disorders of Presynapse
A
Botulism
lambert-eaton syndrome
2
Q
NMJ disorders of the synapse
A
Acetylholinesterase inhibitors
3
Q
NMJ disorders of the postsynapse
A
Myasthenia gravis
snake venom
4
Q
Myasthenia gravis
A
- Anti-acetylcholine receptor antibodies attack the postsynaptic muscle membrane
- DECREASES the number of receptors and BLOCKING the remaining receptors
Fatigability and fluctuation
5
Q
Lambert Eaton syndrome
A
- Anti-Calcium CHannel antibodies attack the presynatpic neuron membrane and PREVENT ACETYLCHOLINE RELEASE
6
Q
Botulism
A
- Botulinum toxin acts at the PRESYNPATIC NEURON membrane and PREVENT THE RELEASE OF ACETYLCHOLINE
7
Q
When to initiate mechanical ventilation
A
- negative inspiratory force (NIF) less negative than -30 cmH2O
- Forced vital capacity <15-20ml/kg
- Significant hypoxemia
- patient distress
- Inability to protect the airway (maintain patency, swallow secretions, etc)
8
Q
Myasthenia gravis vs lambert eaton
A
MG VS LE
Post-synapse vs Pre-synapse
thymus cancer vs Lung cancer
Ocular/upper extremities vs Hip girld
normal on stretch reflexes vs hypoactive or absent reflexes
symptoms worsen on stim vs symptoms improve
