KOMP Grant

Question 1

Aim 1a

Answer 1

Provide expression data and identify the onset of the phenotype

Question 2

Aim1b

Answer 2

Provide a basic molecular characterization of novel mutant phenotypes

Question 3

Aim1c

Answer 3

Conditional analysis of select novel KOMP alleles

Question 4

Four panel IF

Answer 4

SMA
FoxA1
Sox2
DAPI

Question 5

Anticipated phenotypic outcomes from Aims1a and b and further analysis

Answer 5

1) Altered yolk sac development
2) Maternal/fetal connection defects
3) Failed cardiac development
4) Embryonic turning defects
5) Anterior defects/failure in neural tube closure
6) Defects in endoderm patterning or organogenesis

Question 6

Alleles considered for 1c conditional analysis

Answer 6

1) Aim 1a/b null embryos display defects in yolk sac development
2) The gene expressed in the yolk sac VE and at least in the DE
3) A conditional-ready live mouse, sperm, embryos or ES cells is available through KOMP

Question 7

Ppox

Answer 7

004

Question 8

Got2

Answer 8

003

Question 9

Arpcla

Answer 9

005

Question 10

Rik

Answer 10

006

Question 11

Tedc2

Answer 11

001

Question 12

Pgm1

Answer 12

002

Question 13

Exoc314

Answer 13

007

Question 14

Alg3

Answer 14

008

Question 15

Kctd5

Answer 15

009