Komisky Motor Disorder Pharm

Question 1

FDA approved botulinum

Answer 1

Only A and B

Question 2

Propranolol

Answer 2

Rx for ET
SE: bradycardia, hypotension, erectile dysfunction
Beta blocker 2 receptor antagonists

Question 3

Primidone

Answer 3

RX: for ET, beta 2 receptor antagonist
SE: imbalance, sedation, vertigo

Question 4

Propranolol LA

Answer 4

For ET

Not as effective as propranolol and Primidone

Question 5

Surgical intervention for ET

Answer 5

Thalamotomy and deep brain stimulation

Question 6

N acetyl cysteine

Answer 6

Given to ppl with HD

Helps reduce oxidative stress by contributing to glutathione

Question 7

HD medications for GABA

Answer 7

DA antagonist (chlorpromazine)
GABA agonist (Baclofen)

Question 8

Fluoxetine

Answer 8

Used for depression in HD

Question 9

Clozapine

Answer 9

Used for rigidity in HD

Question 10

Quetiapine

Answer 10

Used for rigidity in HD

Question 11

Tetrabenazine

Answer 11

Used for chorea with HD
inhibits reuptake and storage of dopamine, norepinephrine, serotonin, histamine
Adverse rxns: allergic reaction, blue/purple patches on skin, changes in behavior or thoughts of hurting yourself or others, sweating, confusion, uneven heartbeat, muscle stiffness
SE: cough, runny nose, body aches, tiredness, decreased appetite

Question 12

Clonidine and guanfacine

Answer 12

Alpha 2 adrenergic agonist for Tourette’s

Question 13

Haleperidol or pimozide

Answer 13

Blocks dopamine. Used for severe Tourette’s

Question 14

Riluzole

Answer 14

For ALS, extends survival 60-90 days
Enhance reuptake of glutamate by astrocytes and neurons
Blocks post synaptic NMDA and kainate receptors. As well as voltage dependent sodium channel

Question 15

Spasticity drugs (4)

Answer 15

Tizanidine
Baclofen (GABA b agonist, SE: drowsy, nausea, weakness, seizures with withdrawal)
Benzodiazepines
Dantrolene ( affect muscle directly)

Question 16

Medications that exacerbate RLS/PLM

Answer 16

Diphenhydramine
Metoclopramide
Prochlorperazine
Chlordiazepoxide
Antipsychotics and antidepressants

Question 17

Medicine for RLS

Answer 17

Benzodiazepines
Low potency opioids
Levodopa
Dopamine agonists

Question 18

Blepharospasm

Answer 18

Botox type A
Inhibits acetylcholine release at NMJ 
Onset: 3-5 days, lasts 3-6 months
90% excellent response to 2-4 injections
Side effects: ptosis, weakness of eyelid closure, blurred and double vision, lacrimation abnormalities, asymmetric smile and drool