knowledge

Question 1

What is HLA subtype associated with Graves disease?

Answer 1

DR3

B27: Psoriatic arthritis
DQ2/DQ8: Celiac disease
DR3: DM type 1, SLE, Graves disease, Hashimoto disease, Addison disease
DR4: RA, DM type1, Addison disease

Question 2

what are the symptoms of primary hyperaldosteronism?

Answer 2

hypertension, Na↑, K↓ because of the low renin.
by zona glomerulosa of the adrenal gland.

Question 3

two things with hypoglycemia elevate?

Answer 3

insulin and C-peptide
due to drugs or insulinoma
insulin acts via binding to a tyrosine kinase receptor

Question 4

*disease name
symptom: cyanosis for newborn, pulmonary arteries blood has more oxygen than ascending aorta
Echo: aorta leaves RV(anterior) and pulmonary trunk leaves LV(posterior)

Answer 4

D-transposition of great arteries(TGA)
完全大血管転位症
it’s caused by the failure of the aorticopulmonary septum to spiral→Jatene surgery

Question 5

drug name of Ca channel blocker for heart disease and that mechanism

Answer 5

Verapamil, Diltiazem
AV node conduction velocity
PSVT, AFに有効