Know your cytokines Flashcards
B7
On: APCs
Funct.: 2nd sig. of act. for T-Cells
Pairing: CD28 on T-Cells
CD-2
On: TCells
Funct.: adhesion molecule
Pairing: APC or Target cell
CD28
On: TCell
Funct.: Binds B7 as 2nd sig. of Act. TCells
Pairing: B7 on APCs
CD3 complex
On: Tcell
Funct.: Moves alpha and beta subunits of TCR to cell surface and does signal transduction
Pairing: TCR
CD34
On: HEV of 2nd Lymph.
Funct.: Binds to L-Selectin for adhesion
Pairing: L-Selectin
CD40
On: B-Cell
Funct.: Survival Sig. for aff. mat.
Pairing: CD40 Ligand on T-helper
CD40 ligand
On: T Helper Cells
Funct.: Triggers Affinity Maturation
Pairing: CD40
Chemokine
On: HEV 2nd Lymph Tiss.
Funct.: activates LFA-1
Pairing: LFA-1
CR2
On: B-Cell
Funct.: Co-Receptor on Bcells, binds comp. fragments
Pairing: Breakdown products of C3b
DC-CK (Dendritic Cell Cytokine)
On: Dendritic Cells
Funct.: attracts T cells
Pairing: T Cells
Fas Ligand
On: NK Cells + Act. T Cells
Funct.: Binding Fas triggers apoptosis
Pairing: Fas
Fc-gammaRIII
On: NK Cell Surface
Funct.: Binds IgG bound to infected host cells
Pairing: IgG Fc Region
Fc-epsilonRI
On: Mast Cells, Eosinophils
Funct.: Binds IgE
Pairing: Fc portion of IgE
FoxP3
By: Treg cells
Funct.: Regulates T Cell differentiation. May also initiate differentiation to Treg Cells
GlyCAM-1
On: HEV on 2nd Lymph. Tissues
Funct.: Diapedesis/entry of naive T Cell into 2nd lymph.
Pairing: L-Selectin
ICAM-1
On: APC or Target Cell
Funct.: Adhesion molecule
Pairing: LFA-1
Ig-alpha/Ig-beta complex
On: B Cell
Funct.: Signal transduction unit for B Cells
Pairing: BCR
LFA-1
On: Effector T Cell
Funct.: Adhesion Molecule, diapedesis
Pairing: ICAM-1 on APC
L-selectin
On: Naive T Cells
Funct.: Diapedesis/entry of naive T Cells to 2nd Lymph
Pairing: addressins: CD34 and GlyCAM-1
PECAM-1
On: endothelial Cells
Funct.: Modulates transmigration
Pairing:
VCAM-1
On: Vascular epithelium
Funct.: binds to VLA-4
Pairing: VLA-4
VLA-4
On: effector T Cell
Funct.: Binds Vascular Epithelium, entry to site of inflammation
Pairing: VCAM-1
IFN-gamma
Secreted by: Th1 Effector cells, CD8 T Killers
Function: Signals Th0 cells to become Th1 cells; upregulates macrophage activity; activates acute phase response; induces iron storage, inhibits erythropoietin prod.
IFN-alpha and beta
Secreted by: Virus-infected host cells
Funct.: upregulates MHC-I on adjacent cells; activates NK cells
GM-CSF
Secreted by: NK Cells
Funct.: Modulates macrophage activity
TNF-alpha
Secreted by: Macrophages
Funct.: Activates acute phase response; Causes endothelial cell retraction and leakage. Induces ICAM-1 and IFN-gamma
TNF-beta
Secreted by: macrophages
Funct.: causes endothelial cell leakage and induces ICAM and Ig Superfamily
TGF-beta
Secreted by: macrophages
Funct.: Fibroblast migration and proliferation, monocyte chemotaxis; induces VEGF production
EGF
Secreted by: Macrophages
Funct.: Fibroblast migration and proliferation
FGF
Secreted by: macrophages
Funct.: fibroblast migration and proliferation, monocyte chemotaxis, promotes collagen synthesis
PDGF
Secreted by: Macrophages
Funct.: fibroblast migration and proliferation, monocyte chemotaxis, promotes collagen synthesis
VEGF
Secreted by: hypoxic cells
Funct.: Angiogenesis
IL-1
Secreted by: Macrophages, and NK Cells
Funct.: Activates acute phase reaction, responsible for inducing fever, endothelial cell retraction, modulates macrophage activity, induces expression of ICAM and other Ig Superfamily members
IL-2
Secreted by: T-Cells
Funct.: Reqd. for proliferation of T-Cells
IL-3 (Loc/Func.)
Location: Bone Marrow
Funct.: Induces macrophage differentiation
IL-4 (Loc/Func./Sec. By)
Secreted by: Th2 CD4 Cells
Funct.: Signals Th0 to become Th2, activates B cells, promotes class switching to IgE
Loc.: germinal center
IL-5 (Loc/Func./Sec. By)
Secreted by: Th2 CD4 cells
Funct.: Signals Th0 to become Th2, activates B cells, signal B lymphoblasts to plasma cells, promotes class switching to IgA
Loc.: medullary cords of 2nd lymph, germinal cent.
IL-6 (Loc./Func./Sec. By)
Secreted by: Macrophages, Th2 CD4 cells
Funct.: Act. acute phase response, induces CRP, Th0 ->Th2, Act. B Cells, B-Cells->Plasma Cells
Loc.: Medullary cords of 2nd lymph, germinal center
IL-7 (func.)
Func.: survival of memory T-Cell and developing B-Cells
IL-8 (Func.)
Func.: chemical gradient for chemotaxis, stimulates release of histamine
IL-10
Secreted by: macrophages
Funct.: anti-inflammatory
IL-12
Secreted by: macrophages
Funct.: Signals Th0 -> Th1, induces IFN-gamma prod. in T Cells and NK cells.
Credits:
Thanks to Robert Hester for putting the information for this packet together. It wouldn’t have been possible without you.
Credits:
Thanks to Robert Hester for putting the information for this packet together. It wouldn’t have been possible without you.
