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Cytokines > Know your cytokines > Flashcards

Know your cytokines Flashcards

1
Q

B7

A

On: APCs
Funct.: 2nd sig. of act. for T-Cells
Pairing: CD28 on T-Cells

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2
Q

CD-2

A

On: TCells
Funct.: adhesion molecule
Pairing: APC or Target cell

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3
Q

CD28

A

On: TCell
Funct.: Binds B7 as 2nd sig. of Act. TCells
Pairing: B7 on APCs

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4
Q

CD3 complex

A

On: Tcell
Funct.: Moves alpha and beta subunits of TCR to cell surface and does signal transduction
Pairing: TCR

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5
Q

CD34

A

On: HEV of 2nd Lymph.
Funct.: Binds to L-Selectin for adhesion
Pairing: L-Selectin

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6
Q

CD40

A

On: B-Cell
Funct.: Survival Sig. for aff. mat.
Pairing: CD40 Ligand on T-helper

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7
Q

CD40 ligand

A

On: T Helper Cells
Funct.: Triggers Affinity Maturation
Pairing: CD40

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8
Q

Chemokine

A

On: HEV 2nd Lymph Tiss.
Funct.: activates LFA-1
Pairing: LFA-1

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9
Q

CR2

A

On: B-Cell
Funct.: Co-Receptor on Bcells, binds comp. fragments
Pairing: Breakdown products of C3b

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10
Q

DC-CK (Dendritic Cell Cytokine)

A

On: Dendritic Cells
Funct.: attracts T cells
Pairing: T Cells

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11
Q

Fas Ligand

A

On: NK Cells + Act. T Cells
Funct.: Binding Fas triggers apoptosis
Pairing: Fas

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12
Q

Fc-gammaRIII

A

On: NK Cell Surface
Funct.: Binds IgG bound to infected host cells
Pairing: IgG Fc Region

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13
Q

Fc-epsilonRI

A

On: Mast Cells, Eosinophils
Funct.: Binds IgE
Pairing: Fc portion of IgE

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14
Q

FoxP3

A

By: Treg cells

Funct.: Regulates T Cell differentiation. May also initiate differentiation to Treg Cells

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15
Q

GlyCAM-1

A

On: HEV on 2nd Lymph. Tissues
Funct.: Diapedesis/entry of naive T Cell into 2nd lymph.
Pairing: L-Selectin

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16
Q

ICAM-1

A

On: APC or Target Cell
Funct.: Adhesion molecule
Pairing: LFA-1

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17
Q

Ig-alpha/Ig-beta complex

A

On: B Cell
Funct.: Signal transduction unit for B Cells
Pairing: BCR

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18
Q

LFA-1

A

On: Effector T Cell
Funct.: Adhesion Molecule, diapedesis
Pairing: ICAM-1 on APC

19
Q

L-selectin

A

On: Naive T Cells
Funct.: Diapedesis/entry of naive T Cells to 2nd Lymph
Pairing: addressins: CD34 and GlyCAM-1

20
Q

PECAM-1

A

On: endothelial Cells
Funct.: Modulates transmigration
Pairing:

21
Q

VCAM-1

A

On: Vascular epithelium
Funct.: binds to VLA-4
Pairing: VLA-4

22
Q

VLA-4

A

On: effector T Cell
Funct.: Binds Vascular Epithelium, entry to site of inflammation
Pairing: VCAM-1

23
Q

IFN-gamma

A

Secreted by: Th1 Effector cells, CD8 T Killers
Function: Signals Th0 cells to become Th1 cells; upregulates macrophage activity; activates acute phase response; induces iron storage, inhibits erythropoietin prod.

24
Q

IFN-alpha and beta

A

Secreted by: Virus-infected host cells

Funct.: upregulates MHC-I on adjacent cells; activates NK cells

25
Q

GM-CSF

A

Secreted by: NK Cells

Funct.: Modulates macrophage activity

26
Q

TNF-alpha

A

Secreted by: Macrophages

Funct.: Activates acute phase response; Causes endothelial cell retraction and leakage. Induces ICAM-1 and IFN-gamma

27
Q

TNF-beta

A

Secreted by: macrophages

Funct.: causes endothelial cell leakage and induces ICAM and Ig Superfamily

28
Q

TGF-beta

A

Secreted by: macrophages

Funct.: Fibroblast migration and proliferation, monocyte chemotaxis; induces VEGF production

29
Q

EGF

A

Secreted by: Macrophages

Funct.: Fibroblast migration and proliferation

30
Q

FGF

A

Secreted by: macrophages

Funct.: fibroblast migration and proliferation, monocyte chemotaxis, promotes collagen synthesis

31
Q

PDGF

A

Secreted by: Macrophages

Funct.: fibroblast migration and proliferation, monocyte chemotaxis, promotes collagen synthesis

32
Q

VEGF

A

Secreted by: hypoxic cells

Funct.: Angiogenesis

33
Q

IL-1

A

Secreted by: Macrophages, and NK Cells
Funct.: Activates acute phase reaction, responsible for inducing fever, endothelial cell retraction, modulates macrophage activity, induces expression of ICAM and other Ig Superfamily members

34
Q

IL-2

A

Secreted by: T-Cells

Funct.: Reqd. for proliferation of T-Cells

35
Q

IL-3 (Loc/Func.)

A

Location: Bone Marrow

Funct.: Induces macrophage differentiation

36
Q

IL-4 (Loc/Func./Sec. By)

A

Secreted by: Th2 CD4 Cells
Funct.: Signals Th0 to become Th2, activates B cells, promotes class switching to IgE
Loc.: germinal center

37
Q

IL-5 (Loc/Func./Sec. By)

A

Secreted by: Th2 CD4 cells
Funct.: Signals Th0 to become Th2, activates B cells, signal B lymphoblasts to plasma cells, promotes class switching to IgA
Loc.: medullary cords of 2nd lymph, germinal cent.

38
Q

IL-6 (Loc./Func./Sec. By)

A

Secreted by: Macrophages, Th2 CD4 cells
Funct.: Act. acute phase response, induces CRP, Th0 ->Th2, Act. B Cells, B-Cells->Plasma Cells
Loc.: Medullary cords of 2nd lymph, germinal center

39
Q

IL-7 (func.)

A

Func.: survival of memory T-Cell and developing B-Cells

40
Q

IL-8 (Func.)

A

Func.: chemical gradient for chemotaxis, stimulates release of histamine

41
Q

IL-10

A

Secreted by: macrophages

Funct.: anti-inflammatory

42
Q

IL-12

A

Secreted by: macrophages

Funct.: Signals Th0 -> Th1, induces IFN-gamma prod. in T Cells and NK cells.

43
Q

Credits:

Thanks to Robert Hester for putting the information for this packet together. It wouldn’t have been possible without you.

A

Credits:

Thanks to Robert Hester for putting the information for this packet together. It wouldn’t have been possible without you.

Cytokines (1 decks)

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