Kirks And Ettinger Flashcards
What are the 3 causes of sick sinus syndrome?
1- mutation in cardiac Na channels or smooth muscles
2- dysfunction of ryanodine receptors
3- fibrosis
Which breed is predisposed to persistent atrial standstill?
English springer spaniel
Which 4 breeds are predisposed to second degree AV block ?
Chow-chow
Cocker
German pointer
Labrador
Neurocardiogenic reflex is mediated by which cardiac fibers ?
C
Hycoscyamine/methylxantine and terbutaline are which types of drug and can be use to address which heart disease?
Anticholinergic and B-agonist
AV-block
What are the 5 classes of anti-arrhythmic
(NoBody Kills Cats # Dog) I- Na (Lidocaine) II- B-blocker (atenolol) III- K potassium channel blockers (sotalol, amiodarone) IV - Ca (diltiazem) V - Digoxin
What triggers cascade of compensatory effects happens with CHF
Vasoconstriction (from sympathetic, RAAS and endothelial system)
Retention of sodium / water (via altered renal blood flow and NE)
Inflammation and growth promoting factors
NT proBNP over 1500 increases risks of decompensation within ___ months
6-12 months
What is the primary treatment for atrial tear ?
Decrease atrial pressure through preload reduction
NO pimobendan
What are the 5 main causes of pulmonary hypertension ?
Idiopathic, TE, pulmonary diseases, L-R shunt, L CHF
Mutation in the gene for pyruvate dehydrogenase kinase 4 is seen is which breed, with which heart disease ?
Doberman pinsher
DCM
What are the 4 breeds mainly predisposed to DCM
Doberman, Irish Wolffhouds, great danes and Newfoundlands
S3 can be heard in dogs with DCM because of ____
Increased left ventricular filling pressure
Genetic deletion mutation in the 3’ untranslated region of striatin (desmosomal protein) is seen with which heart disease ?
ARVC
In patients with ARVV, a positive response is considered when ___
you see > 80-85% of reduction in VPC
Which pressor should be use in animals with CHF?
Dobutamine
Name the 3 elements in the Virchow’s triad
Endothelial injury
Blood stasis
Hypercoagulable state
Chronic pericardial effusion results in ___ sided heart failure
right
In heartworm diseases, Antigens detect ___ and Antibodies detect ____
Reproductive tract of mature female
Exposure to L4
How long does the HW cycle takes in dogs ? cats?
6-7 months
7-8 months
Which stage does the female mosquito ingest following a blood meal from an infected animal?
L1
Which stages develop within mosquito ?
L1-L3
Caval syndrome in HW infection is associated with ___
High burden, severe PH and right ventricular dysfunction
do not use adulticide at that stage
Which intracellular negative bacteria contribute to pulmonary and renal inflammation through WSP protein in animals affected by HWD
Wolbachia
During endocarditis, disruption of the endothelium triggers coagulation on the damaged endothelium, which allows bacteria to bind, if ____
They possess adhesive molecules or are resistant to platelet bactericial proteins or evade IS by internalization
Which 4 breeds are predisposed to endocarditis
German Shepherd, boxer, golden and labrador
Which are the 3 most common bacterial involve in mitral endocarditis ?
Staphyloccocus, strep, and E.coli
Bartonella affects which valve ?
Aortic
Which bacterial infection can lead to myocarditis in cats ?
Toxoplasmosis
PDA results in communication between ______ and ____
Descending aorta
Main pulmonary artery
(both will be dilated on radiographs)
Which 2 breeds are predisposed to subvalvular PS ?
Boxer and English bulldog
this form cannot be balloon dilated
PS in inherited in ___
Beagles
PS results in __ sided heart failure
right
Which 2 breeds are genetically predisposed to SAS?
Newfoundland and Dogue de Bordeaux
In which breed SAS is familial ?
Golden
SAS impedes ventricular ejection, which results in ___ ___ ___ hypertrophy
Left venticular concentric hypertrophy
Positive atropine response test signifies that bradycardia is caused by ___
high vagal tone
TVD is inherited in ___
Labrador
TVD results in which 2 changes on ECG
Splintered QRS and P pulmonale
Shunting across VSD is from ___ ventricle into ___ ventricle
Left (high pressure)
Right (low pressure)
What is the target BP of dogs and cats
Dogs: 140-150 mmHg
Cats: < 160 mmHg
The sum of all forces that oppose the ejection of blood from the ventricles is name ___
Afterload
Response to heart failure includes those 5 mechanisms:
- Increase adrenergic nervous system
- RAAS activation
- overexpression of atrial and brain natriuretic peptides
- Increased endothelin and arginin vasopressin
- Proinflammatory cytokines
What are the effects of natriuretic peptides ?
-Opposite of RAAS
natriuresis, vasorelaxation, inhibit release of renin and aldosterone
Which natriuretic peptide has the longest half-life
BNP
Release of ADH depend on ___ and ____
osmolality, hypovolemia
What are the 3 roles of adrenomedullin
Natriuretic
Vasodilator
Inotropin
What is the law of laplace ?
It says that pressure overload increases wall
thickness
(up until the myocardial perfusion is overwheelmed = hypoxia = myocardial death and fibrosis)
What are the causes of PAC? (4)
Atrial lesions, Hyperthyroidism, hemangiosarcoma, digitalis toxicosis
What non-cardiac causes can result in VPC ? (5)
HypoK Anemia Trauma GDV Abdominal mass
Which breed is predisposed to torsade de pointe?
Dalmatian
What is the treatment for torsade de pointe?
Mg
What electrolyte abnormality and which medication can result in 3rd degree AV block?
HyperK
Dexmedetomidine
Which BBB is an incidental finding and which is related to left ventricular enlargement?
Right
Left
In regard to excitability, what is the result of those electrical abnormalities?
- hypokaliemia
- hyperkalemia
- hypocalcemia
- decrease resting membrane potential (excitability)
- increases resting potential
- lowers threshold
Which breed is predisposed to SSS?
Female miniature schnauzer
Which congenital disease leads to a split second sound on auscultation?
ASD
Which breed is predisposed to VSD?
Maine coon
Which breed is predisposed to tricuspid valve insufficiency?
Male Labrador
Which breed is predisposed to mitral valve dysplasia?
Bull terrier
PS results in which kind to hypertrophy?
Concentric right ventricular
Aortic stenosis is seen in which breed?
Newfoundland
Aortic stenosis results in which hypertrophy?
Concentric left ventricular
Which congenital heart disease can predispose to endocarditis?
Aortic stenosis
Which 2 breeds are predisposed to mitral valve disease?
CKC and dachshund
Which side of heart enlargement leads to taller wave? Which to prolonged wave ?
Right
Left
What are the major criteria for endocarditis?
- Vegetative lesion / erosion/ abscess
- New valvular insufficiency
- 2-3 positive blood cultures
What are the minor criteria for endocarditis?
- fever
- > 15 kg dog
- TE
- immune mediated disease
- bartonella serology
- 1 positive blood culture
Doberman are predisposed to DCM from which mutation?
PDK4
Which breed (2) get DCM has young dogs?
Portuguese Water Dogs
Toy Manchester terrier
Fibrous fatty infiltrate of the right ventricular free wall is associated with which disease?
ARVC
Which breed is predisposed to HCM?
Male Maine coon
Which mutation predispose Maine coon to HCM?
MyBPC
Endomyocardial fibrosis with distinct tubular lesion bridging the IVS and LVFW result in which heart disease?
Restrictive cardiomyopathy
Cats synthesize taurine from _____
Cysteine
Which nutrient is use exclusively for bile acid conjugation ?
Taurine
Segmental left ventricular hypertrophy, regional hypokinesia, and marked LAE is seen in which heart disease?
Unclassified cardiomyopathy
Which 2 breeds are predisposed to peritoneopericardial hernia?
Maine coon
Weimaraner
Macrocyclic lactone terminates which stage of HWD?
L3 and L4