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Pharmacokinetics > Kinetics BrainScrape CYPs > Flashcards

Kinetics BrainScrape CYPs Flashcards

1
Q

Amiodarone

A

Inhibitor of CYP2C9

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2
Q

Azoantifungals

A

Substrate CYP3A4

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2
Q

Barbiturates

A

Inducer of CYP2C19

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3
Q

Benzos except lorazepam/oxazepam

A

Substrate CYP3A4

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3
Q

Carbamazepine

A

Inducer of CYP 3A4

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3
Q

Caffeine

A

Substrate of CYP1A2

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3
Q

Carbamazepine

A

Inducer of CYP2C9

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4
Q

CCBs

A

Substrate CYP3A4

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5
Q

Charbroiled meat

A

Inducer of CYP1A2

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6
Q

Chlorpromazine (antipsychotics)

A

Substrate of CYP2D6

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8
Q

Chlorzoaxazone

A

Substrate of CYP2E1

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9
Q

Clarithromycin

A

Inhibitor of CYP3A4

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9
Q

Cimetidine

A

Inhibitor of CYP3A4, 1A2, 2C9

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9
Q

Clozapine

A

Substrate of CYP1A2

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9
Q

Cigarette smoke

A

Inducer of CYP1A2, CYP2E1

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9
Q

Cipro

A

Inhibitor of CYP1A2

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9
Q

Bisoprolol

A

Substrate of CYP2D6

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11
Q

Codeine (opioid analgesics)

A

Substrate of CYP2D6

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12
Q

Cruciferous vegetables

A

Inducer of CYP1A2

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13
Q

Dexamthasone

A

Inducer of CYP 3A4, 2C9

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13
Q

Diazepam

A

Substrate of CYP2C19

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14
Q

Diltiazem

A

Inhibitor of CYP1A2

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15
Q

Disulfram

A

Inhibitor of CYP2E1

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16
Q

Ecainide (antiarrhthmics)

A

Substrate of CYP2D6

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17
Q

Efavirenz

A

Inducer of CYP 3A4

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17
Q

Enflurance

A

Substrate of CYP2E1

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18
Q

Enoxacin

A

Inhibitor of CYP1A2

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19
Q

Erythryomycin

A

Inhibitor of CYP3A4

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20
Q

Ethanol

A

Inducer and Substrate of CYP2E1

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21
Q

Fluoxetime (most SSRIs)

A

Substrate of CYP2D6

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21
Q

Fluconazole

A

Inhibitor of CYP2C9

22
Q

Fluoxetine

A

Inhibitor of CYP2D6, 2C19

22
Q

Fluvastatin

A

Substrate of CYP2C9

24
Q

Fluvoxamine

A

Most potent Inhibitor of CYP1A2, also inhibitor of CYP2C9, 2C19

25
Q

Garlic

A

Inhibitor of CYP2E1

26
Q

Glibenclamide

A

Substrate of CYP2C9

28
Q

Glimipiride

A

Substrate of CYP2C9

29
Q

Glipizide

A

Substrate of CYP2C9

30
Q

Grapefruit Juice

A

Inhibitor of CYP3A4

31
Q

Halothane

A

Substrate of CYP2E1

32
Q

HMG-CoA Reductase Inhibitor except Pravastatin

A

Substrate CYP3A4

34
Q

Isoflurane

A

Substrate of CYP2E1

35
Q

Isoniazid

A

Substrate of CYP2E1

37
Q

Itraconazole

A

Inhibitor of CYP2C9

37
Q

Isoniazid

A

Inducer of CYP2E1

38
Q

Ketoconazole

A

Inhibitor of CYP3A4

39
Q

Macrolide antibiotics except Azithromycin

A

Substrate CYP3A4

41
Q

Methoxyflurane

A

Substrate of CYP2E1

42
Q

Metronidazole

A

Inhibitor of CYP2C9

43
Q

Nevirapine

A

Inducer of CYP 3A4

44
Q

Norfloxacin

A

Inhibitor of CYP1A2

45
Q

NSAIDs

A

Substrate of CYP2C9

46
Q

Olanzapine

A

Substrate of CYP1A2

48
Q

Omeprazole

A

Substrate of CYP2C19 and Inhibitor of CYP2C19

inducer of CYP1A2

50
Q

Paroxetine

A

Inhibitor of CYP2D6

51
Q

Phenobarb

A

Inducer of CYP3A4, 1A2, 2C9,

52
Q

Phenytoin

A

Inducer of CYP3A4, 2C9,

54
Q

Primidone

A

Inducer of CYP 3A4, 1A2,

54
Q

Quinidine

A

Inhibitor of CYP2D6

56
Q

R-warfarin

A

Substrate of CYP1A2

58
Q

Rifabutin

A

Inducer of CYP 3A4

60
Q

Rifampin

A

Inducer of CYP 3A4, 1A2, 2C9, 2C19

61
Q

Riluzole

A

Substrate of CYP1A2

62
Q

Ritonavir

A

Inhibitor of CYP3A4, 1A2, 2E1

64
Q

Ropivacaine

A

Substrate of CYP1A2

66
Q

S-mephenytoin

A

Substrate of CYP2C19

67
Q

S-warfarin

A

Substrate of CYP2C9

68
Q

Sevoflurane

A

Substrate of CYP2E1

69
Q

SJW

A

Inducer of CYP3A4, 2E1, 2C9

70
Q

Steroids (BC, corticosteroids)

A

Substrate CYP3A4

71
Q

Sulfonamides

A

Inhibitor of CYP2C9

72
Q

Tacrine

A

Substrate of CYP1A2

73
Q

Theophylline

A

Substrate of CYP1A2

74
Q

Tolbutamide

A

Substrate of CYP2C9

75
Q

Tricyclic antidepressants

A

Substrate of CYP2D6

76
Q

Troleandomycin

A

Inhibitor of CYP3A4

77
Q

zileuton

A

Inhibitor of CYP1A2

Pharmacokinetics (1 decks)

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