Kidney Stones Flashcards
another name for kidney stones
nephrolithiasis
pathophysiology of kidney stones
saturation, super saturation, nucleation, crystal growth, crystal retention, stone formation
most common kind of kidney stones
calcium stones
causes of calcium stones
- hypercalciuria (high Ca in urine)
- hyperthyroidism/hyperparathyroidism
- excess vitamin D
- glucocorticoid use
- renal tubular acidosis
- idiopathic
3 most common types of stones
calcium, oxalate, uric acid
Causes of oxalate stones
Inflammatory bowel syndrome - causes fat malabsorption - bile acid and fatty acid in GI tract increases permeability to oxalate - also unabsorbed FAs bind to CA so there is less Ca to bind to oxalate
Endogenous synthesis of oxalate is proportional to
Lean body mass
Causes of oxalate stones
excess vitamin c (especially CKD)
Low pyridoxone (B6) - will leave you with excess glyoxylate which turns to oxylate
Eating excess oxylate in your diet
Risk factors for kidney stones
Diabetes
Obesity
Metabolic syndrome
IBD
High oxylate foods
Rhubarb Spinach Strawberries Chocolate Wheat bran/whole wheat products Nuts Beets Tea Turmeric
Uris acid is end product of
Purine metabolism
Uris acid stones that crystallize out of your blood and travel to toe or ankle cause
Gout
Uric acid stones are caused by
Part from endogenous source (tissue catabolism)
Part from diet
From super-saturation when pH of urine
Other risk factors for Uric acid stones
IBD - leads to acidic urine due to dehydration
Diabetes
Foods high in purines
Foods high in purines
Organ meats Anchovies Herrings Sardines Meat-based broth Gravies