Kidney and Urinary Tract Disorders Flashcards

1
Q

UTI in children <3mo

A

ALL infants <3mo w/suspicion of UTI or if seriously ill should be referred immediately to hospital
IV co-amox 5-7d
followed by PO proph

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2
Q

Infants >3mo and children w/acute pyelonephritis/Upper UTI

A

If dip +ve for leucocyte esterases or nitrites send culture and start abx
PO trimethoprim 7d
If not IV co-amox 2-4d then stepdown

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3
Q

Children w/cystitis/lowerUTI

A
Dysuria NO systemic Sx
PO trimeth/nitro for 3d
Advise:
seek attention if still unwell after 48hrs of abx
fluids
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4
Q

USS DMSA MCUG

A
infants w/atypical or recurrent UTI should have USS
DMSA within 4-6m of acute infection if:
- <3y w/atypical/recurrent
- >3y w/recurrent
MCUG if recurrent or if abnormal USS
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5
Q

Medical measures to prevent UTI

A

Aim: ensure washout of organisms that ascending and the presence of aggressive organisms in the stool perineum and under foreskin
High fluid intake to produce high urine output
Complete bladder emptying
Good hygiene
Lactobacillus acidophilus: probiotic

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6
Q

FU of children w/recurrent UTI, renal scarring or reflux

A
Urine dipsticked with any non-specific illness incase it is UTI, MC+S
Low dose abx proph. possible
Circumcision in boys?
anti-VUR surgery
Regular BP checking
Urinalysis for proteinuria (CKD)
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7
Q

Summary of UTI in children

A

<3m refer immediately to paeds
>3m w/upper UTI: consider admission otherwise PO abx 7-10d
>3m w/lower UTI PO ABx 3d
Recurrent: ?prophylaxis

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8
Q

Enuresis

A

most children dry day and night by 5 (day only by 4)
Primary bedwetting (w/o daytime Sx):
- Children <5: reassure is normal, ensure easy access to toilet at night (potty next ti bed), encourage bladder and bowel emptying before bed, consider reward sysytem
Children >5: if <2/wk then watch and see, if long term treatment required:
1st line: enuresis alarm w/reward system
2nd:desmopressin (restrict fluid 1hr before to 8hr after)
Offer desmo for short term control eg school trip

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9
Q

If Mx for enuresis fails

A

Restart previously successful in combination w/desmo and alarm
TCA and anitmuscarinics can be considered in cases

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10
Q

Referral for enuresis

A

NOT responded to 2 courses of Mx, refer to 2ndry care, specialist clinic or paediatrician

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11
Q

Advice on enuresis

A

NOT anyone’s fault
Volume exceeds capacity but doesnt wake child
Reassure almost all will become dry as bladder grows and they learn sensation
Pass regularly, esp. before bed
Caffeine drinks avoided (before bed)
Healthy diet
Easy access to toilet
waterproof mattress
Neutral attitude as not to embarrass
Older children may prefer to change it themselves
Waking in the night does NOT promote long term dryness
Positive support
support: ERIC

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12
Q

Primary bedwetting w/daytime Sx

A

Refer to secondary care/enuresis clinic

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13
Q

Secondary bedwetting

A

occurs after previously been dry for 6m
Causes that can be manged in primary care: UTI, constipation
Specialist referral:
DM, recurrent UTI, psych, family problems, developmental delay, neurological/physical problems

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14
Q

Summary of enuresis

A
Look for causes: constipation/diabetes
Fluid intake, toilet behaviour
reward system
1st line <7y = alarm
desmopressin 1L if >7 or short term control needed
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15
Q

Nephrotic syndrome

A
PO steroids (60mg/m^2 pred)
After 4wks dose reduced
If no resp. after 4wks or have atypia may have more complex Dx and need biopsy
NB. renal histology of steroid sens. NS is usually normal on light micros. but fusion of podocyes on EM
- minimal change Dx
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16
Q

Cx of nephrotic syndrome

A

Hypovolaemia
thrombosis
infection
hypercholesterolaemiea

17
Q

Henoch-Schonlein Purpura

A

Most will resolve 4wks
P/I for arthalgia
If scrotal involvement of severe odema or severe abdo pain give PO pred
IV corticosteroids in pts w/nephrotic range proteinuria and those w/declining renal function
Rental trx in end stage dx
FU: BP and renal function

18
Q

Urinary tract calculi in children

A

Conservative Mx, IV fluids, consider morphine, antiemetics
Bacterial inf: co-trim/nitro
Small stones: medical expulsive Mx Tamsulosin
Larger stones: surgical (ESWL, uteroscopy)

19
Q

AKI General Mx

A

USS may be useful to identify cause (obstruction, small kidneys in CKD, large bright kidneys w/loss of corticomedullary diff.)
Diuretics when necessary (oedema while awaiting dialysis)
Fluid restriction may behelpful
Consider renal replacement therapy if any of below not responding to Mx:
- hyperkal
- pulmonary oedema and fluid overload
- acidosis
-uraemia (pericarditis,encephalopathy)
Prognosis good unless underlying cause

20
Q

Pre-renal failure

A

hypovolaemia
little sodium excreted
fluid replacement and circ, support

21
Q

Renal failure

A

monitor water and electrolytes
high calorie normal protein deed decreases catabolism, uraemia, hyperkalaemia
Most common AKI in UK
- HUS, ATN (multisystem failure)

22
Q

Post-renal failure

A

Refer imm. to urology:
pyelonephrosis
obstructed solitary kidney
bilateral upper UT obs.
Cx of UTI caused by urological obstruction
Assessment of site of obs.
Relief achieved by nephrostomy or bladder cath.

23
Q

Indications for dialysis in AKI

A
Failure of conservative Mx
Hyperkalaemia
Severe hypo/hypernatraemia
Pulmonary oedema or severe  htn due to vol overload
Severe met acidosis
Multisystem failure
24
Q

(J)HUS

A

Ix: FBC, blood smear, renal function, coagulation, LDH, haptoglobin, stool culture
Consult neph/haem
ADMIT those w/typical presentation

25
Q

Management of HUS

A

Supportive:
monitor urine and fluid balance
avoid cardiopulomnary overload
Keep BP normal (CCBs bc ACE reduce ren. perfusion)
Avoid: Abx, antidiarr, narcotic opiods, NSAIDs
Long term FU necessary (persistent proteinuria and hypertension, and progress of CKD)
Atypical HUS: no diarrhoeal prodrome, ?familial, requent relapse (high risk CKD + HTN + mortality)

26
Q

CKD Ix and aims

A

serum creatinine, urinalysis, renal USS

aim: prevent Sx and metabolic abnormality allow growth and development, preserve renal function

27
Q

CKD diet

A

anorexia and vomiting common
calorie supp. or NG feed often necessary
Protein intake must be sufficient to maintain growth and normal albumin but not allowing accumulation of toxic end products of metabolism

28
Q

Prevention of renal osteodystrophy

A

Decreased vitD activation -> PO4 retentiom and hypocal.
secondary hyperparathyroidism
osteitis fibrosa cystica + osteomal.
Phosphate restriction w/reducing milk, using CaCO3 as a PO4 binder or activated VitD supplements may help

29
Q

Control of salt and water balance, and acidosis in CKD

A

Many will have obligatory loss of water and salt
need salt supplements and lots of water
Mx w/bicarb prevent acidosis

30
Q

Anaemia in CKD

A

Reduced EPO prod. and circ of BM toxic metabolites causes anaemia
Respond well to sc. recombinant human EPO

31
Q

Hormonal abnormalities in CKD

A

GH resistance a feature (high GH poor growth)
Recomb. GH effective for up to 5y of use
Many w/ stage 4/5 will have delayed puberty or subnormal pubertal growth spurt