KIDNEY Flashcards
define : azotemia
increased BUN + creatinine b/c of decreased glomerular filtration rate
azotemia + clinical manifestations
uremia
define : nephritic syndrome
commonly seen in?
mild proteinuria, HTN, hematuria
acute poststreptococcal glomerulonephritis
define: rapidly progressive glomerulonephritis
nephritic syndrome with rapid decline in GFR
define: nephrotic syndrome
heavy proteinuria(3.5 gm/day), hypoalbuminemia, severe edema, hyperlipidemia, lipiduria
is acute renal failure reversible
YES
** 4 stage of chronic renal failure **
- diminished renal reserve = GFR 50% of normal
- normal BUN/creatinine - asymptomatic - renal insufficiency = GFR 20-50% normal
- azotemia,anemia, HTN - chronic renal failure = GFR 20-25% of normal
- metabolic acidosis, hyperkalemia, edema - end-stage renal disease = GFR less than 5% of normal
systemic diseases associated w/ glomerular disease
amyloidosis, SLE, diabetes, vasculitis
components of glomerular capillary wall
- fenestrated endothelial layer
- GBM-electronegativity
- visceral epithelial cells (podocytes)- filtration slits
- responsible for PROTEINS
supported by mesangial cells
define : crescents
which molecule is responsible for formation?
accumulation of epithelial cells with infiltrating leukocytes
-FIBRIN
ant-GBM nephritis attacks what?
NCI domain of collagen type IV
Heymann Nephritis characteristics
electron dense deposits along SUBEPITHELIAL
GRANULAR - IF microscopy
** Anti-GMB antibody induced glomerulonephritis
LINEAR- IF microscopy
deposit in the basement membrane
IF GRANULAR associated w?
circulating and in situ immune complex nephritis
-granular b/c they deposit everywhere along glomeruli
progressive renal damage leads to which two major histologic characteristics?
- FSGS
2. tubulointerstitial fibrosis