keypoints per task Flashcards
1
Q
intro to memory and animal models (1.1)
- what are the neural systems of memory?
A
- implicit
- explicit memory (episodic + semantic)
- example human (h.m, anterograde and temporally graded amnesia) and rodent (contextual fear conditioning)
2
Q
intro to memory and animal models (1.2)
- what are the neural circuits and molecular mechanisms of memory?
A
- circuit - ltp , schaffer collaterals
- molecular - normal vs ltp , NMDA-AMPA , shaffer collaterals
3
Q
intro to memory and animal models (1.3)
- what are animal paradigms to study memory?
A
rodents - morris water maze, contextual fear conditioning, radial arm maze
bats - 2 d vs 3d +place cells
nhp -hard
4
Q
intro to memory and animal models (1.4)
- what are the imaging methods for animal research?
A
- electrophysiology
- two-photon imaging
- neural pertubation methods (electrical micro stimulation + chemo/opto genetics )
5
Q
spatial representations (2.1) - what are the spatial representations of the hippo?
A
- place cells
- head direction cells
- grid cells
- border cells
- other - speed and object vector cells
6
Q
spatial representations (2.2) - why are there spatial cells?
A
- How does the activity of the different cell types allow us to navigate? 1. All other spatial cells provide input for place cells - If place cells are the substrate of the cognitive map, then perhaps all the other cells provide the necessary input to create the map (For example, border cells indicate the proximity of boundaries, head direction cells provide anchoring to external cues, etc) or some suggest input from grid cells of different scales to the hippocampus can generate a place cell
7
Q
spatial representations (2.3) - what is the relationship between spatial rap and memories?
A
- wood et al (2000) - predictive coding
- klaus et al (2013) - temporal coding
- aranov et al (2017) - auditory coding
8
Q
memory replay (3.1) -what are the 2 dominant theories of hippo function?
A
- consolidation - kim and fanselow (1992)
- imagination
9
Q
memory replay (3.2) - what is hippo replay and function?
A
- reactivation - slow wave sleep + awake time - trajectories
- wilson and mcnaughton (1994) . hebbian plasticity
- swrs , ca3
- functions are many: consolidation, planning, retrieval, imagination, memory maintenance, temporal credit assignment
10
Q
memory replay (3.3) - methods
A
rank order correlations approach - small scale
bayesian decoding approach - large scale, replay trajectory, reverse replay, ratemaps , probability distribution
11
Q
memory replay (3.4) - replay for memory consolidation
A
- swrs
- reverse replay
- olafsdottir (2016)
- foster and wilson (2006)
- girardeau (2009)
- maingret (2016)
- gridchyn (2020) - one of the most important ones
12
Q
memory replay (3.5) - replay for planning
A
- singer (2013)
- jadhav et al. (2012)
- olafsdottir (2017)
- pfeiffer (2013)
- WM
13
Q
memory replay (3.6) - memory replay and immagination?
A
- gupta (2010)
- olafsdottir (2015)
- preplay
14
Q
memory development (4.1) - how do memory capabilities develop/emerge in the first years of life?
A
excitatory neurons glun2a glun2b and camkii infantile amnesia - green and stanton (1982) + campbell (1962) - vargha-khadem (2001) -guskjolen (2018) developmental amnesia
15
Q
memory development (4.2) - what are the molecular changes underlying memory development? (key players?)
A
NMDArs (glun1, glun2a, glun2b) and ampa
camkii
