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Pre-Reg November Exam '24 > Key Drug Interactions > Flashcards

Key Drug Interactions Flashcards

1
Q

Statin + fusidic acid

A

Increased risk of rhabdomyolysis

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2
Q

Statin + ezetimibe

A

Increased risk of rhabdomyolysis

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3
Q

Statin + macrolide

A

Increased risk of rhabdomyolysis

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4
Q

Statin + fenofibrate/nicotinic acid

A

Increased risk of rhabdomyolysis

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5
Q

Lercanidipine + macrolide

A

Contraindicated- due to markedly increased exposure to lercanidipine (BP reduced too much)

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6
Q

Warfarin + metronidazole

A

Increased anticoagulant effect of warfarin

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7
Q

Warfarin + rifampicin

A

Increased metabolism of warfarin, thus reduced anticoagulant effect

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8
Q

Warfarin + macrolide

A

Increased risk of serious haemorrhage and significant elevation in INR

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9
Q

Warfarin + quinolones

A

Increased risk of serious haemorrhage and significant elevation in INR

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10
Q

ACEi + spironolactone

A

Increased risk of hyperkalaemia

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11
Q

ACEi + NSAID

A

Increased risk of renal damage

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12
Q

ACEi + K+ sparing diuretic

A

Increased risk of hyperkalaemia

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13
Q

Amlodipine + simvastatin

A

Increased exposure to simvastatin

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14
Q

Amiodarone + QT prolonging drugs

A

Risk of QT prolongation

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15
Q

Amiodarone + digoxin

A

Increased exposure to digoxin

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16
Q

Amiodarone + simvastatin

A

Increased exposure to simvastatin

17
Q

Which drugs interact with digoxin, increasing serum digoxin?

A
  • P-glycoprotein transport inhibitors e.g. clarithromycin, erythromycin, ritonavir and verapamil
  • Amiodarone
  • Verapamil
  • Macrolides
  • Azole antifungals
  • Cyclosporins

Pre-Reg November Exam '24 (10 decks)

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