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First Aid - Rapid Review > Key Associations > Flashcards

Key Associations Flashcards

1
Q

Actinic (solar) keratosis

A

Precursor to squamous cell carinoma

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2
Q

Acute gastric ulcer associated with CNS injury

A

Cushing’s ulcer (increase ICP stimulates vagal gastric secretion)

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3
Q

Acute gastric ulcer associated with severe burns

A

Curling’s ulcer (greatly reduced plasma volume results in sloughing of gastric mucosa)

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4
Q

Alternating areas of transmural inflammation and normal colon

A

Skip lesions (Crohn’s disease)

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5
Q

Aneurysm, dissecting

A

Hypertension

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6
Q

Aortic aneurysm, abdomina and descending aorta

A

Atherosclerosis

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7
Q

Aortic aneurysm, arch

A

Tertiary syphilis (syphilitic aortitis), vasa vasorum destruction

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8
Q

Aortic aneurysm, ascending

A

Marfan’s syndrome (idiopathic cystic medial degeneration)

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9
Q

Atrophy of the mammillary bodies

A

Wernicke’s encephalopathy (thiamine deficiency causing ataxia, opthalmoplegia, and confusion)

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10
Q

Autosplenectomy (fibrosis and shrinkage)

A

Sickle cell anemia (hemoglobin S)

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11
Q

Bacterial meningitis (adults and elderly)

A

Streptococcus penumoniae

N. meningitidis (#1 teens)

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12
Q

Bacteria associated with gastritis, peptic ulcer disease, and stomach cancer

A

H. pylori

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13
Q

Bacterial meningitis (newborns and kids)

A

Newborn (0-6 mo.)

  • Group B streptococcus
  • E. Coli
  • Listeria
(Children 6 mo - 6 yr) 
S. pneumoniae
Neisseria meningitidis
Haemophilus influenzae type B
Enteroviruses
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14
Q

Benign melanocytic nevus

A

Spitz nevus (most common in first two decades)

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15
Q

Bleeding disorder with GpIB deficiency

A

Benard-Soulier syndrome (defect in platelet adhesion to von Willebrand’s factor)

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16
Q

Brain tumor (adults)

A

Supratentorial: metastasis > astrocytoma (including gliblastoma multiforme) > meningioma > schwannoma

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17
Q

Brain tumor (kids)

A

Infraterntorial: pilocytic astrocytoma, medulloblastoma (cerebellum), ependymoma

Supratentorial: craniopharyngioma (cerebrum) (benign childhood tumor, most common supratentorial childhood tumor - don’t confuse with pituitary adenoma)

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18
Q

Breast Cancer

A

Infiltrating ductal carcinoma (in the U.S., 1 in 9 women will develop breast cancer)

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19
Q

Breast mass

A

Fibrocystic change, carcinoma (in postmenopausal women)

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20
Q

Breast tumor (benign)

A

Fibroadenoma

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21
Q

Cardiac [Primary] tumor (kids)

A

Rhabdomyoma, often seen in tuberous sclerosis

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22
Q

Cardiac manifestation of lupus

A

Libman-Sacks endocarditis (nonbacterial, affecting both sides of mitral valve)

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23
Q

Cardiac tumor (adults)

A

Metastasis, primary myxoma (4:1 left to right atrium; “ball and valve” )

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24
Q

Cerebellar tonsillar herniation

A

Chiari malformation (often presents with progressive hydrocephalus or syringomyelia)

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25
Q

Chronic arrhythmia

A

Atrial fibrillation (associated with high risk of emboli)

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26
Q

Chronic atrophic gastritis (autoimmune)

A

Predisposition to gastric carcinoma (can also cause pernicious anemia)

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27
Q

Clear cell adenocarcinoma of the vagina

A

DES exposure in utero

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28
Q

Compression fracture

A

Osteoporosis

  • type I: postmenopausal woman
  • type II: elderly man or woman
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29
Q

Congenital adrenal hyperplasia, hypotension

A

21-hydroxylase deficiency

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30
Q

Congenital cardiac anomaly (most common)

A

VSD

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31
Q

Congenital conjugated hyperbilirubinemia (black liver)

A

Dubin-Johnson syndrome (inability of hepatocytes to secrete conjugated bilirubin into bile)

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32
Q

Constrictive pericarditis

A

Tuberculosis (developing world)

Systemic lupus erythematosus (developed world)

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33
Q

Coronary artery involved in thrombosis

A

LAD> RCA > LCA

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34
Q

Cretinism

A

severe fetal hypothyroidism

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35
Q

Cushing’s syndrome

A
  • Iatrogenic Cushing’s (from corticosteroid therapy)
  • Adrenocortical adenoma (secretes excess cortisol)
  • ACTH-secreting pituitary adenoma
  • Paraneoplastic Cushing’s (due to ACTH secretion by tumors)
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36
Q

Cyanosis (early; less common)

A

Tetralogy of Fallot, transposition of great vessels, truncus arteriosus

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37
Q

Cyanosis (late; more common)

A

VSD, ASD, PDA

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38
Q

Death in CML

A

Blast crisis

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39
Q

Death in SLE

A

Lupus nephropathy

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40
Q

Dementia

A

Alzheimer’s disease, multiple infarcts

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41
Q

Demyelinating disease in young women

A

Multiple sclerosis

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42
Q

DIC

A

Severe sepsis, obstetric complications, cancer, burns, trauma, major surgery

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43
Q

Dietary deficit

A

Iron

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44
Q

Diverticulum in pharynx

A

Zeneker’s diverticulum (diagnosed by barium swallow)

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45
Q

Ejection click

A

Aortic/pulmonic stenosis

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46
Q

Esophageal cancer

A

Squamous cell carcinoma (worldwide); adenocarcinoma (U.S)

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47
Q

Food poisioning (exotoxin mediated)

A

S. aureus, B. cereus

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48
Q

Glomerulonephritis (adults)

A

Berger’s disease (IgA nephropathy)

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49
Q

Gynecologic malignancy

A

Endometrial carcinoma (most common in U.S.); cervical carcinoma (most common worldwide)

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50
Q

Heart murmur, congenital

A

Mitral valve prolapse

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51
Q

Heart valve in bacterial endocarditis

A

Mitral > aortic (rheumatic fever), tricuspid (IV drug abuse)

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52
Q

Helminth infection (U.S.)

A

Enterobius vermicularis (pinworm), Ascaris lumbricoides (giant roundworm)

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53
Q

Hematoma-epidural

A

Rupture of middle meningeal artery (trauma; lentiform shaped)

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54
Q

Hematoma-subdural

A

Rupture of bridging veins (crescent shaped)

55
Q

Hemochromatosis

A

Multiple blood transfusions or hereditary HFE mutation (can result in Cirrhosis, CHF, “bronze diabetes,” and increase risk of hepatocellular carcinoma)

56
Q

Hepatocellular carcinoma

A

Cirrhotic liver (associated with hepatitis B and C and with alcoholism)

57
Q

Hereditary bleeding disorder

A

von Willebrand’s disease

58
Q

Hereditary harmless jaundice

A

Gilbert’s syndrome (benign congenital unconjugated hyperbilirubinemia)

59
Q

HLA-B27

A

Ankylosing spondylitis, Reiter’s syndrome, IBD, psoriatic arthritis

60
Q

HLA-DR3 or -DR4

A

Diabetes mellitus type 1, rheumatoid arthritis, SLE

61
Q

Holosystolic murmur

A

VSD, tricuspid regurgitation, mitral regurgitation

62
Q

Hypercoagulability, endothelial damage, blood stasis

A

Virchow’s triad (results in venous thrombosis)

63
Q

Hypertension, Secondary

A

Renal disease

64
Q

Hypoparathyroidism

A

Accidental excision during thyroidectomy

65
Q

Hypopituitarism

A

Pituitary adenoma (usually benign tumor)

66
Q

Infection [Secondary] to blood transfusion

A

Hepatitis C

67
Q

Infections in chronic granulomatous disease

A

Staphylococcus aureus, E. coli, Aspergillus (catalase positive)

68
Q

Kidney stones

A
  • Calcium =radiopaque
  • Struvite (ammonium Mg Phos) = radiopaque (formed by urease-positive organisms such as Proteus vulgaris, Coagulase Neg Staphylococcus, Klebsiella)
  • Uric acid = radiolucent
69
Q

Late cyanotic shunt (uncorrected left to right becomes right to left)

A

Eisenmenger’s syndrome (caused by ASD, VSD, PDA; results in pulmonary hypertension/polycythemia)

70
Q

Liver disease

A

Alcoholic cirrhosis

71
Q

Lysosomal storage disease (most common)

A

Gaucher’s disease

72
Q

Male cancer

A

Prostatic carcinoma

73
Q

Malignancy associated with noninfectious fever

A

Hodgkin’s lymphoma

74
Q

Malignancy (kids)

A

ALL, medulloblastoma (cerebellum)

75
Q

Mental retardation

A

Down syndrome, fragile X syndrome

76
Q

Metastases to bone

A

Prostate, breast > lung > thyroid, testes

77
Q

Metastases to brain

A

Lung > breast > genitourinary > osteosarcoma > melanoma > GI

78
Q

Metastases to liver

A

Colon&raquo_space; stomach, pancreas

79
Q

Mitochondrial inheritance

A

Disease occurs in both males and females, inherited through females only

80
Q

Mitral valve stenosis

A

Rheumatic heart disease

81
Q

Mixed (UMN and LMN) motor neuron disease

A

ALS

82
Q

Myocarditis

A

Coxsackie B

83
Q

Nephrotic syndrome (adults)

A

Focal segmental glomerulosclerosis

84
Q

Nephrotic syndrome (kids)

A

Minimal change disease

85
Q

Neuron migration failure (defective migration of GnRH cells and formation of olfactory bulb)

A

Kallmann syndrome (hypogonadotropic hypogonadism and anosmia)

86
Q

Nosocomial Pneumonia

A

Klebsiella, E. coli, Pseudomonas aeruginosa

87
Q

Obstruction of male urinary tract

A

BPH

88
Q

Opening snap

A

Mitral stenosis

89
Q

Opportunistic infection in AIDS

A

Pneumocystic jirovecii (formerly carinii) pneumonia

90
Q

Osteomyelitis

A

S. aureus

91
Q

Osteomyelitis in sickle cell disease

A

Salmonella

92
Q

Osteomyelitis with IV drug use

A

Pseudomonas, S. aureus

93
Q

Ovarian metastasis from gastric carcinoma or breast cancer

A

Krukenberg tumor (mucin-secreting signet-ring cells)

94
Q

Ovarian tumor (benign, bilateral)

A

Serous cystadenoma

95
Q

Ovarian tumor (malignant)

A

Serous cystadenocarcinoma

96
Q

Pancreatitis (acute)

A

Gallstones, alcohol

97
Q

Pancreatitis (chronic)

A

Alcohol (adults), cystic fibrosis (kids)

98
Q

Patient with ALL/CLL/ AML/CML

A

ALL: child, CLL: adult > 60, AML: adult ~ 65, CML: adult 30-60

99
Q

Pelvic inflammatory disease (bugs)

A

Chlamydia trachomatis, Neisseria gonorrhoeae

100
Q

Philadelphia chromosome t(9; 22) (bcr-abl)

A

CML (may sometimes be associated with ALL/AML)

101
Q

Pituitary tumor

A

Prolactinoma, somatotropic “acidophilic” adenoma

102
Q

Primary amenorrhea

A

Turner syndrome (45, XO)

103
Q

Primary bone tumor (adults)

A

Multiple myeloma

104
Q

Primary hyperaldosteronism

A

Adenoma of adrenal cortex

105
Q

Primary hyperparathyroidism

A

Adenomas, hyperplasia, carcinoma

106
Q

Primary liver cancer

A

Hepatocellular carcinoma (chronic hepatitis, cirrhosis, hemochromatosis, alpha1 antitrypsin deficiency)

107
Q

Pulmonary hypertension

A

COPD

108
Q

Recurrent inflammation/thrombosis of small/medium vessels in extremities

A

Buerger’s disease (strongly associated with tobacco)

109
Q

Renal tumor

A

Renal cell carcinoma: associated with von Hippel-Lindau and cigarette smoking; paraneoplastic syndromes (EPO, renin, PTH, ACTH)

110
Q

Right heart failure due to a pulmonary cause

A

Cor pulmonale

111
Q

S3 (protodiastolic gallop)

A

Increased ventricular filling (left to right shunt, mitral regurgitation, LV failure [CHF])

112
Q

S4 (presystolic gallop)

A

Stiff/hypertrophic ventricle, Atrial kick (LA must push against stiff LV) Associated with hypertrophic cardiomyopathy, restrictive cardiomyopathy, aortic stenosis

113
Q

Secondary hyperparathyroidism

A

Hypocalcemia of chronic kidney disease (decreased Vit D)

114
Q

Sexually transmitted disease

A

Chlamydia (usually coinfected with gonorrhea)

115
Q

SIADH

A

Small cell carcinoma of the lung

116
Q

Site of diverticula

A

Sigmoid colon

117
Q

Sites of atherosclerosis

A

Abdominal aorta >coronary artery > popliteal artery > carotid artery.

118
Q

Stomach cancer

A

Adenocarinoma

119
Q

Stomach ulcerations and high gastrin levels

A

Zollinger-Ellison syndrome (gastrinoma of duodenum or pancreas)

120
Q

t(14;18)

A

Follicular lymphomas (bcl-2 activation)

121
Q

t(8;14)

A

Burkitt’s lymphoma (c-myc activation)

122
Q

t(9;22)

A

Philadelphia chromosome, CML (bcr-abl fusion)

123
Q

Temporal arteritis

A

Risk of ipsilateral blindness due to thrombosis of opthalmic artery; polymyalgia rheumatica

124
Q

Testicular tumor

A

Seminoma

125
Q

Thyroid cancer

A

Papillary carcinoma

126
Q

Most common of all tumors in women

A

Leiomyoma (fibroids = estrogen dependent, not precancerous)

127
Q

Tumor of infancy

A

Hemangioma (usually regresses spontaneously by childhood)

128
Q

Tumor of the adrenal medulla (adults)

A

Pheochromocytoma (usually benign)

129
Q

Tumor of the adrenal medulla (kids)

A

Neuroblastoma (malignant)

130
Q

Most common type of Hodgkin’s

A

Nodular sclerosis (vs. mixed cellularity, lymphocytic predominance, lymphocytic depletion)

131
Q

Most common type of non-Hodgkin’s

A

Diffuse large cell

132
Q

UTI

A

E. coli, Staphylococcus saprophyticus (young women)

133
Q

Viral encephalitis affecting temporal lobe

A

HSV-1

134
Q

Vitamin deficiency (U.S.)

A

Folate (pregnant women are at high risk; body stores only 3- to 4-month supply; prevents neural tube defects)

First Aid - Rapid Review (4 decks)

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