Key assets in MM Flashcards
Abecma: INN, company, MoA and Target
ide-cel, BMS, CAR-T, BCMA
Abecma: what is it approved in?
5L+ RRMM
Abecma: what trial gained its approval and when?
Phase 2 KarMMa trial, 2021
Mezigdomide: company, MoA
BMS, CELMOD
What drugs are approved in 5L+ RRMM (Drug names + INNs)
Blenrep (belantamab mafadorin), Abecma (ide-cel), Carvykti (cilta-cel)
What drugs are approved in NDMM (TI)(Drug name + INN)
Darzalex, daratumumab
What combinations are approved in 2L+ RRMM
XVd, Dara+Pd, Dara +Kd, IsaKd
What combination is approved in 3L+ RRMM
Isa + Pd
What combinations are approved in 2L+ including Amgen’s Kyprolis?
DKd, IsaKd
Empliciti: INN, company, MoA and target
elotuzumab, BMS, CS1 mAb
Iberdomide: company, MoA
BMS, CELMOD
Pomalyst: INN, company, MoA
pomalidomide, BMS, IMiD
Revlimid: INN, company, MoA
lenalidomide, BMS, IMiD
zevor-cel: company, MoA and target
Cargsen, BCMA, CAR-T
Pepaxti: INN, company, MoA
melflufen, oncopeptides, alkyliting agent
Elranatamab: company, MoA and target
Pfizer, BCMA TCE
Venclexta/Venclyxto: INN, company, MoA and target
venetoclax, Abecma, BCL2i (small molecule)
Sarclisa: INN, company, MoA and target
isatuximab, Sanofi, CD38 mAb
Darzalex: INN, company, MoA and target
daratumumab, JNJ, CD38 mAb
Velcade: INN, company, MoA and target
bortezomib, Takeda, PI
Ninlaro: INN, company, MoA and target
ixazomib, Takeda, PI
Modakafusp alpha: company + target
Takeda + CD38
Tecvayli: INN, company, MoA + Target
teclistamab, JNJ, BCMA TCE
Nexpovio/Xpovio: INN, company + Target
selinexor, Karyopharm, XPOi (small molecule)
Blenrep: INN, company, MoA + Target
belantamab mafadotin, GSK, BCMA ADC
talquetamab: company, MoA + target
JNJ, GPRC5D, mAbs
PHE885: company + target
Novartis + BCMA CAR-T
What are Regeneron’s BCMA TCE’s?
RGN5458 and RGN5459
alnuctamab: company, MoA and target
BMS, BCMA TCE
What’s the KarMMa-3 trial
Phase 3 trial of Abecma (ide-cel) vs. SoC in 3-5L RRMM
What do the KarMMa trials evaluate (Drug name + INN)
Abecma (ide-cel)
What do the DREAMM trials evaluate (Drug name + INN)
Blenrep (belantamab mafadotin)
What do the MajesTEC-3 trials evaluate
teclistamab
What do the MagnetisMM trials evaluate
elranatamab
What do the MonumenTAL trials evaluate
talquetamab
What do the TRIMM trials evaluate
talquetamab
What does the PERSEUS trial evaluate
Phase 3, DVRd vs. VRd in TE NDMM
What does the GRIFFIN trial evaluate
Phase 2, DVRd vs VRd in TE NDMM
What do the PERSEUS and GRIFFIN trials evaluate
DVRd vs VRd in TE NDMM
What’s the difference between the PERSEUS and GRIFFIN trials
PERSEUS is Phase 3, GRIFFIN is Phase 2
What does the ADVANCE trial evaluate
Phase 2, DKRd vs KRd
What does the CEPHEUS trial evaluate
Phase 3, DKRd vs KRd
What do the ADVANCE and CEPHEUS trials evaluate
DKRd vs KRd
What’s the difference between the ADVANCE and the CEPHEUS trials?
Advance is Phase 2, CEPHEUS is Phase 3
What are the key quad trials
PERSEUS, GRIFFIN, ADVANCE, CEPHEUS , GMMG-HD7, ISKIA
What do we want to know about the quad trials?
Timelines for readout
What does the GMMGH7 trial study
IsaVRd vs VRd
What does the ISKIA trial study
IsaKRd vs KRd
Based on which trial was teclistamab FDA approved in October 2022
Phase 1/2 MajesTEC-1 trial in 4L+ RRMM
In what line of therapy was teclistamab FDA approved? What type of approval was it
5L+ RRMM, accelerated approval
What does the Phase 3 MajesTEC-9 trial evaluate? When was it posted?
Tec monotherapy vs. PVd or Kd in 2-4L RRMM; it was posted in October 2022
Whats the earliest approval based on the MajesTEC-9 trial? In what
H1 2026, in 2L+ RRMM (tec monotherapy)
What does the Phase 3 MajesTEC-3 trial evaluate?
Tec + Dara vs DPd or DVd in 2L+ RRMM
What do the CAMMA trials evaluate?
cevostamab
What’s Roche’s GPRC5D?
RG6234 (it was previously from Regeneron)
RG6234: company, MoA
Roche, GPRC5D TCE
What does the Phase 3 IMROZ trial evaluate
Sarlisa + VRd in TI NDMM
What does the Phase 3 CANOVA trial evaluate
Ven _ d vs. Pd in 3L+ RRMM