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MM 101 > Key assets in MM > Flashcards

Key assets in MM Flashcards

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1
Q

Abecma: INN, company, MoA and Target

A

ide-cel, BMS, CAR-T, BCMA

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2
Q

Abecma: what is it approved in?

A

5L+ RRMM

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3
Q

Abecma: what trial gained its approval and when?

A

Phase 2 KarMMa trial, 2021

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4
Q

Mezigdomide: company, MoA

A

BMS, CELMOD

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5
Q

What drugs are approved in 5L+ RRMM (Drug names + INNs)

A

Blenrep (belantamab mafadorin), Abecma (ide-cel), Carvykti (cilta-cel)

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6
Q

What drugs are approved in NDMM (TI)(Drug name + INN)

A

Darzalex, daratumumab

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7
Q

What combinations are approved in 2L+ RRMM

A

XVd, Dara+Pd, Dara +Kd, IsaKd

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8
Q

What combination is approved in 3L+ RRMM

A

Isa + Pd

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9
Q

What combinations are approved in 2L+ including Amgen’s Kyprolis?

A

DKd, IsaKd

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10
Q

Empliciti: INN, company, MoA and target

A

elotuzumab, BMS, CS1 mAb

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11
Q

Iberdomide: company, MoA

A

BMS, CELMOD

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12
Q

Pomalyst: INN, company, MoA

A

pomalidomide, BMS, IMiD

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13
Q

Revlimid: INN, company, MoA

A

lenalidomide, BMS, IMiD

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14
Q

zevor-cel: company, MoA and target

A

Cargsen, BCMA, CAR-T

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15
Q

Pepaxti: INN, company, MoA

A

melflufen, oncopeptides, alkyliting agent

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16
Q

Elranatamab: company, MoA and target

A

Pfizer, BCMA TCE

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17
Q

Venclexta/Venclyxto: INN, company, MoA and target

A

venetoclax, Abecma, BCL2i (small molecule)

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18
Q

Sarclisa: INN, company, MoA and target

A

isatuximab, Sanofi, CD38 mAb

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19
Q

Darzalex: INN, company, MoA and target

A

daratumumab, JNJ, CD38 mAb

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20
Q

Velcade: INN, company, MoA and target

A

bortezomib, Takeda, PI

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21
Q

Ninlaro: INN, company, MoA and target

A

ixazomib, Takeda, PI

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22
Q

Modakafusp alpha: company + target

A

Takeda + CD38

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23
Q

Tecvayli: INN, company, MoA + Target

A

teclistamab, JNJ, BCMA TCE

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24
Q

Nexpovio/Xpovio: INN, company + Target

A

selinexor, Karyopharm, XPOi (small molecule)

25
Q

Blenrep: INN, company, MoA + Target

A

belantamab mafadotin, GSK, BCMA ADC

26
Q

talquetamab: company, MoA + target

A

JNJ, GPRC5D, mAbs

27
Q

PHE885: company + target

A

Novartis + BCMA CAR-T

28
Q

What are Regeneron’s BCMA TCE’s?

A

RGN5458 and RGN5459

29
Q

alnuctamab: company, MoA and target

A

BMS, BCMA TCE

30
Q

What’s the KarMMa-3 trial

A

Phase 3 trial of Abecma (ide-cel) vs. SoC in 3-5L RRMM

31
Q

What do the KarMMa trials evaluate (Drug name + INN)

A

Abecma (ide-cel)

32
Q

What do the DREAMM trials evaluate (Drug name + INN)

A

Blenrep (belantamab mafadotin)

33
Q

What do the MajesTEC-3 trials evaluate

A

teclistamab

34
Q

What do the MagnetisMM trials evaluate

A

elranatamab

35
Q

What do the MonumenTAL trials evaluate

A

talquetamab

36
Q

What do the TRIMM trials evaluate

A

talquetamab

37
Q

What does the PERSEUS trial evaluate

A

Phase 3, DVRd vs. VRd in TE NDMM

38
Q

What does the GRIFFIN trial evaluate

A

Phase 2, DVRd vs VRd in TE NDMM

39
Q

What do the PERSEUS and GRIFFIN trials evaluate

A

DVRd vs VRd in TE NDMM

40
Q

What’s the difference between the PERSEUS and GRIFFIN trials

A

PERSEUS is Phase 3, GRIFFIN is Phase 2

41
Q

What does the ADVANCE trial evaluate

A

Phase 2, DKRd vs KRd

42
Q

What does the CEPHEUS trial evaluate

A

Phase 3, DKRd vs KRd

43
Q

What do the ADVANCE and CEPHEUS trials evaluate

A

DKRd vs KRd

44
Q

What’s the difference between the ADVANCE and the CEPHEUS trials?

A

Advance is Phase 2, CEPHEUS is Phase 3

45
Q

What are the key quad trials

A

PERSEUS, GRIFFIN, ADVANCE, CEPHEUS , GMMG-HD7, ISKIA

46
Q

What do we want to know about the quad trials?

A

Timelines for readout

47
Q

What does the GMMGH7 trial study

A

IsaVRd vs VRd

48
Q

What does the ISKIA trial study

A

IsaKRd vs KRd

49
Q

Based on which trial was teclistamab FDA approved in October 2022

A

Phase 1/2 MajesTEC-1 trial in 4L+ RRMM

50
Q

In what line of therapy was teclistamab FDA approved? What type of approval was it

A

5L+ RRMM, accelerated approval

51
Q

What does the Phase 3 MajesTEC-9 trial evaluate? When was it posted?

A

Tec monotherapy vs. PVd or Kd in 2-4L RRMM; it was posted in October 2022

52
Q

Whats the earliest approval based on the MajesTEC-9 trial? In what

A

H1 2026, in 2L+ RRMM (tec monotherapy)

53
Q

What does the Phase 3 MajesTEC-3 trial evaluate?

A

Tec + Dara vs DPd or DVd in 2L+ RRMM

54
Q

What do the CAMMA trials evaluate?

A

cevostamab

55
Q

What’s Roche’s GPRC5D?

A

RG6234 (it was previously from Regeneron)

56
Q

RG6234: company, MoA

A

Roche, GPRC5D TCE

57
Q

What does the Phase 3 IMROZ trial evaluate

A

Sarlisa + VRd in TI NDMM

58
Q

What does the Phase 3 CANOVA trial evaluate

A

Ven _ d vs. Pd in 3L+ RRMM

MM 101 (1 decks)

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