Ketorolac

Question 1

What is the brand/trade name for ketorolac?

Answer 1

• Toradol

_{Anesthesia Guidebook - Episode 19: Anesthesia Top Drawer Run Down - Part 3
UpToDate - Ketorolac: Drug Information}

Question 2

What is the pharmacologic category/class of ketorolac?

Answer 2

• Nonsteroidal anti-inflammatory drug (NSAID)

_{Anesthesia Guidebook - Episode 19: Anesthesia Top Drawer Run Down - Part 3
UpToDate - Ketorolac: Drug Information}

Question 3

What is the mechanism of action of ketorolac?

Answer 3

• inhibits COX-1 and 2, decreasing formation of prostaglandins → antipyretic, analgesic, anti-inflammatory effects

_{Anesthesia Guidebook - Episode 19: Anesthesia Top Drawer Run Down - Part 3
UpToDate - Ketorolac: Drug Information}

Question 4

What is the common dosing of ketorolac for perioperative analgesia?

Answer 4

• 15-30 mg
  new research is showing that 10 mg may be just as effective

_{Anesthesia Guidebook - Episode 19: Anesthesia Top Drawer Run Down - Part 3
Master Anesthesia
UpToDate - Ketorolac: Drug Information}

Question 5

What is the onset of action for ketorolac?

Answer 5

• ~30 minutes

_{Anesthesia Guidebook - Episode 19: Anesthesia Top Drawer Run Down - Part 3
UpToDate - Ketorolac: Drug Information}

Question 6

What is the duration of action for ketorolac?

Answer 6

• 4-6 hours

_{Anesthesia Guidebook - Episode 19: Anesthesia Top Drawer Run Down - Part 3
UpToDate - Ketorolac: Drug Information}

Question 7

What are two common precautions/contraindications for the use of toradol?

Answer 7

• bleeding risks
• renal failure

check with surgeon before administering/ordering

_{Anesthesia Guidebook - Episode 19: Anesthesia Top Drawer Run Down - Part 3
UpToDate - Ketorolac: Drug Information}