Ketone Body Synthesis (only in Liver)

Question 0

Acetoacetyl CoA + Acetyl CoA ->

Answer 0

HMG CoA (3-Hydroxyl-3-methylglutaryl-CoA) + CoA

Enzyme: HMG CoA Synthase (unique to ketone body synthesis, only in liver)

Question 1

2 Acetyl CoA ->

OR

Fatty Acyl CoA (fatty acid oxidation)

Answer 1

CoA + Acetoacetyl CoA

Enzyme: Thiolase
OR
See Fatty Acid Oxidation

Question 2

HMG CoA ->

Answer 2

Acetyl CoA + Acetoacetate

Enzyme: HMG CoA lyase (unique to ketone body synthesis, in liver)

Question 3

Acetoacetone (+ NADH + H) ->

2 Answers

Answer 3

CO2 + Acetone (Spontaneous)

OR
3-Hydroxybutyrate + NAD+
Enzyme: 3-Hydroxybutyrate Dehydrogenase