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Biomedicine > Katie Cytology, Basic Genetics & Histology > Flashcards

Katie Cytology, Basic Genetics & Histology Flashcards

1
Q

What does anatomy mean?

A

The study of the structures that form the body

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2
Q

What is Physiology

A

How parts of the body works.

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3
Q

What is pathology

A

Study of abnormalities from normal function

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4
Q

What are the 7 characteristics of Life

A

Metabolism = Sum of all chemical processes in the body creating energy in the form of ATP
Responsiveness = Ability to respond to changes in the environment
Movement = Movement of the whole organism or individual organs cells and the structures inside cells.
Reproduction = Formation of new cells or production of new individual
Growth = increase in size or number
Differentiation = development to a specialised state.
Vital Force/Life Force/QI

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5
Q

What is vital life Force

A

Energy that enables all living things to self heal, maintain equilibrium or homeostasis and preserve life by adapting to environmental changes.

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6
Q

4 Characteristics of death

A

Loss of heartbeat
Absence of breathing
Loss of brain function
No vital life force/Life force/Qi

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7
Q

Define Homeostasis

A

A condition of equilibrium (balance) in the body’s internal environment that is maintained by the body’s own regulatory processes.

It is dynamic and ever changing working within certain narrow limits to ensure optimal body functioning.

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8
Q

What are the 7 main Physiological variables of homeostasis

A 
Core body temperature 36.5 - 37
PH levels 7.35 - 7.45
Blood pressure
Water and electrolyte levels
Carbon Dioxide CO2 and Oxygen O2
Blood glucose 
Flow of life force
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9
Q

What are the names of the 3 body fluids

A 
Intracellular = fluid inside the cells
Extracellular = fluid outside the cells
Interstitial = fluid between the cells
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10
Q

What is fluid in the blood called

A

Blood Plasma

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11
Q

What is fluid in the blood called

A

Blood Plasma

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12
Q

What is the function of interstitial fluid

A

Fluid that moves substances back and forth between it and the blood.

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13
Q

What are the 4 control systems of Homeostasis

A

Disruptors = change the homeostatic parameter
Detectors = receptors that detect the changes often nerves
Control Centre = determines the limits within which parameters should be maintained. Evaluates input and generates output.
Effectors = structures that receive the output

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14
Q

What is lack of Oxygen called

A

Hypoxia

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15
Q

What is the function of the hormone EPO

A

It is the hormone that makes the bone marrow produce more red blood cells.

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16
Q

What is a feedback system

A

A group of receptors and effectors communicating with their control centre.

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17
Q

Explain a negative feedback system

A

The output reverses the input.
The effector response decreases the original stimulus maintaining or restoring homeostasis
e.g increasing or decreasing body temperature/blood pressure/glucose

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18
Q

Explain a positive feedback system

A

Strengthens/amplifies change in one of the body’s controlled conditions. Stimulus progressively increases the response as long as the stimulus is continued.

Examples include - childbirth, milk production, enzyme reactions, blood clotting and immune system

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19
Q

What are the 7 parts of body organisation

A

Atoms and molecules - chemical level
Cells - smallest living units in the body
Tissues - groups of cells that work together to preform a function
Organs - Groups of tissues working together
Systems - related organs that have a comman function
The organism - All parts of the body together
Vital Force - Energy that creates life.

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20
Q

Name 4 body cavities

A

Cranial
Thoracic
Abdominal
Pelvic

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21
Q

Describe 5 points of the Cell Theory

A

All living things are made up of cells and vital life force
Cells are the structural and functional unit of all living things
All cells come from pre-existing cells
Cells contain hereditary information that is passed on through cell division
All energy flow of life (metabolism and life force) occurs within cells.

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22
Q

What is cell memory

A

Describes the ability of cells to remember experiences which influence the vital force in our cells and body. Vital force is free flowing throughout the body of a healthy person and can become blocked creating the possibility of disease.

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23
Q

Definition of pathophysiology

A

Study of changes in the way the body works due to disease

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24
Q

What causes stagnation of energy

A

Caused by many factors such as dietary choices, life style influences, drugs and exposure to harmful substances such as radiation.

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25
Q

what heavy metals accumulate in the body causing damage to cells

A

Aluminium, Mercury and Lead

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26
Q

What diseases is aluminium toxicity linked to

A

Alzheimer’s it can cause damage to neurons in the brain and is also a risk factor for some cancers including breast cancer.

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27
Q

Define Oxidative damage

A

Oxidative damage is an imbalance of free radicals and antioxidants in the body.
It is damage to a structure by a molecule containing oxygen these are known as free radical. They are highly unstable and highly reactive molecules that lack an electron in their atomic structure. These electrons can be donated by antioxidants.

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28
Q

Give an example of antioxidants

A

Vitamin C, E and beta carotene

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29
Q

What can happen from oxidative damage?

A

Damages key cell structures and can cause mutations (this is what happens during the development of cancer)
Cell membranes can be damaged by toxic metals such as mercury ie dental fillings.

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30
Q

What is a prokaryote cell?

A

Bacteria

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31
Q

What is a Eukaryotic Cell

A

Human Cells/Plants/Fungi

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32
Q

Why is the cell membrane semi permeable

A

To allow substance movement in and out of cells.

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33
Q

Explain the structure of the cell membrane

A

Structurally it is Phospholipid bilayer with the lipid tails (fats) on the inside which are hydrophobic (water hating) and phosphate heads on the outside which are hydrophobic (water hating)

The membrane is embedded with trans-membrane proteins

The membrane controls the movement of substances in and out of cells

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34
Q 
What is the chemical formula for the following
Oxygen
Carbon Dioxide
Glucose 
Hydrogen
Potassium 
Chloride
A 
O2
CO2
C6H1206
H+
K+
CL-
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35
Q

What is the function of trans membrane proteins?

A

Transport of substances in and out of cells including the movement of charged particles such as H+ and larger molecules such as glucose C6H1206

Immunological Identity - Helps immune cells recognise our own cells (stops white blood cells attacking our body cells) which creates autoimmune diseases such as Coeliac’s disease

Act as receptors - recognition sites for hormones etc

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36
Q

What are cell junctions and what are the 2 types and where can they be found?

A

Cell junctions are the communication between adjacent cell membranes of tightly packed cells.

  1. Tight junctions - transmembrane proteins fuse cells together to prevent leaking and can be found in the stomach intestines and bladder.
  2. Gap Junctions - Small fluid filled tunnels between neighboring cells can be found in nerve cells and nerve muscle cells.
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37
Q

What is the Nucleus and what does it control

A

Contains the bodies genetic information in the form of DNA. It is the brain of the cell and controls all cell functions.

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38
Q

What is the full name of DNA?

A

Deoxyribonucleic Acid

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39
Q

What is the full name of RNA and what is it’s function?

A

Ribonucleic Acid which is responsible for protein synthesis

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40
Q

Explain the structure of the Nucleus

A

Surrounded by a double layered nuclear membrane which separates the nucleus from the cytoplasm. The membrane is continuous with the rough endoplasmic reticulum.
It contains nuclear pores for substance movement in and out of the nucleus.

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41
Q

What are prokaryote and Eukaryote cells

A

Prokaryote are bacteria cells and Eukaryote are human/animal or fungi cells.

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42
Q

In what 5 ways do prokaryote cells differ from Eukaryote cellsKa

A

Prokaryote cells have no nucleus (DNA located in the Cytoplasm) Eukaryote cells have a membrane bound Nucleus
Prokaryote cells are much smaller than Eukaryote cells
Prokaryote cells are absent of membrane bound organelles, Eukaryote have many
Prokaryote cells have a cell wall - Eukaryote cells do but only in plants and fungi
Prokaryote cells undergo cell division by Binary Fission (rapid mitosis) Eukaryotic cell division involves mitosis

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43
Q

Explain characteristics and functions of the Nucleus list 6 of them

A
  1. Sphere shaped Organelle
  2. It contains genetic information in the form of DNA
  3. Double layered membrane between Nucleus and Cytoplasm
  4. It is continuous with rough ER
  5. It contains a Nucleolus this is where RNA is produced which is essential for protein synthesis
  6. Contains Nuclear pores to allow movement of substances in and out
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44
Q

What is the Cytoskeleton

A

Is a network of protein filaments (microtubules and microfilaments) that extend through the Cytosol.

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45
Q

What 3 functions does the Cytoskeleton assist with

A
  1. Generates movement of cells e.g white blood cells to migrate to site of an injury. They are the organelles that enable muscle contraction.
  2. They give the cell structure and support
  3. Cell division they move cells apart
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46
Q

What organelles produces ATP and what does the abbreviation stand for?

A

Mitochondria

Adenosine Triphosphate

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47
Q

Where is the Mitochondria located

A

Located where oxygen enters the cells towards the outside

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48
Q

Describe the structure of Mitochondria

A

Bean shaped with a double layered membrane with fluid in between. Inner membrane has a series of folds called cristae which produce a vast surface area for chemical reactions.

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49
Q

What cells are thought to contain the most Mitochondria and why.

A

Muscle cells they use ATP to generate muscle contraction

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50
Q

What is the process called that mitochondria use to create ATP

A

Aerobic Respiration

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51
Q

What is the equation for aerobic respiration

A

Glucose + Oxygen > Carbon Dioxide + water + ATP

52
Q

What is the function of Ribosomes

A

Essential for protein synthesis

53
Q

What are the 2 types of Ribosomes and what are their functions

A

Either free (mobile) in the cytoplasm or bound to rough endoplasmic reticulum (stationary)

Free Ribosomes make protein for inside the cell and the those on the Rough ER make protein for outside the cell.

54
Q

What is ER and what is the abbreviation

A

ER stands for Endoplasmic Reticulum it is a network of membranes in the form of flattened sacs. It extends from the nuclear envelope to the cell membrane.

55
Q

What are the 2 types of ER and their function

A

Rough ER - continuous with the nuclear membrane studded with Ribosomes that synthesise and transport proteins.

Smooth ER - has a smooth appearance and contains unique enzymes which
Synthesises (produces) lipids and steroid hormones e.g oestrogen
In the liver the enzymes detoxify e.g alcohol and drugs
In muscle releases enzymes for muscle contraction

56
Q

What is a receptor

A

A structure that allows substances to attach to them

57
Q

Describe the structure of a Chromosome

A

A chromosome consists of a pair of chromatids, joined by a centromere. A chromatid forms from chromatin that tightly coils itself around proteins called histones. These strands of tightly coiled DNA are double-stranded molecules, made up of two chains of nucleotides. Nucleotides consist of three subunits: a sugar, a phosphate group and a base. Likened to a twisted ladder, DNA’s uprights are formed by alternating chains of sugar (deoxyribose) and phosphate units. The four different bases bind to the phosphate in a precise order that makes up the genetic code.

58
Q

What are normal cells called and how many chromosomes do they contain.

A

Somatic cells 46 Chromosomes (23 pairs)

59
Q

What are sex cells called and how many chromosomes do they contain

A

Gametes they have 23 chromosomes

60
Q

What are the units called that are arranged along side the chromosomes called

A

Genes

61
Q

What are Genes and what do they do

A

Genes are subsections of DNA
They hold information to build and maintain cells and pass on genetic information to offspring.
They code for proteins one gene will code for one specific protein.
Only certain genes will be switched on.

62
Q

What pair of chromosomes determine the sex

A

23rd pair

63
Q

What sex do XY Chromosomes dictate

What sex do XX chromosomes dictate

A
  1. Male

2. Female

64
Q

What happens in Mitosis and what are these cells used for

A

A full set of chromosomes is duplicated and evenly distributed into 2 identical daughter cells which are pulled apart by protein filaments of the Cytoskeleton

Used for growth and repair

65
Q

In Mitosis what are the 7 stages of cell reproduction list in the order they happen

A 
Interphase
Prophase
Metaphase 
Anaphase
Telophase
Cytokenesis
66
Q

What happens in interphase

A

Cell grows in size and volume, chromosomes replicate and make 2 copies and prepare for cell division

67
Q

What happens in Prophase

A
  1. Replicated Chromatin becomes tightly coiled
  2. The 2 Chromatoids are joined at the centomere
  3. The Mitotic apparatus appears and consists of 2 centroles and a mitotic spindle formed of micro tubules.
  4. The centroles migate to each side of the cell and the nuclear envelope disappears
68
Q

What happens in Metaphase

A

Chromotids align in the centre of the spindle attached by there centomeres

69
Q

What happens in Anaphase

A

Centomeres separate and one of each pair of sister chromatoids migates to the ends of the spindles and are then pulled to opposite sides of the cell by shortening of the mitotic spindle

70
Q

Telophase

A

Mitotic spindle disappears the Chromosomes uncoil and nuclear envelope appears

71
Q

Cytokineses

A

Cytosol organells and plasma membrane split forming 2 identical daughter cells.

72
Q 
What are rates of Mitosis for the following:
1. Epidermis 
2. Stomach/Intestines
3. Liver 
4. Tastebuds
5 Red blood cells
A
  1. 40 days
  2. 5 days
  3. 5 months
  4. 10 days
  5. 90-120 days
73
Q

All Gametes have a -xxxxx nucleus which means they contain 23 Chromosomes

A

Haploid

74
Q

Somatic Cells have a xxxxxx nucleus?

A

Diploid

75
Q

What is Meiosis

A

The process which sex cells are produced. It produced 4 non identical cells by 2 cell divisions allowing for genetic variability

76
Q

What is the end result of Mitosis and what is there purpose?

A

2 new identical diploid somatic cells. Used for body cell growth and repair

77
Q

What is the end result of Meiosis and what is the purpose

A

4 unique Haploid reproductive cells. Reproduction making Gametes (eggs and sperm)

78
Q

Describe a mutation

A

Mutation is a change in information (DNA sequence)

DNA consists of various sequences of 4 amino acids. A mutation will change this sequence

79
Q

Can mutations be passed on in gametes or somatic cells

A

Mutations in Gametes can be passed on to offspring but in somatic cells cannot be inherited

80
Q

How do mutations occur

A

Either by chance or induced by mutagenic agents such as smoking, radiation, vaccines or Chemo

81
Q

What are the 4 Nucleobases

A

Adenine
Guanine
Thymine
Cytosine

82
Q

What amino acids pair together

A

A goes with T

C goes with G

83
Q

What is phago

A

To eat

84
Q

What does pino mean

A

To drink

85
Q

What does Epi mean

A

On top

86
Q

Thelial

A

Layer

87
Q

What are the structures in the neck sometimes mistaken for

A

Glands they are not they are lymph nodes

88
Q

What is the job of glands

A

Structure the secretes a substance such as enzymes hormones etc

89
Q

Where is epithelial tissue located. Name 7 areas

A

Blood vessels, heart, lungs, reproductive organs, urinary tract Gastrointestinal Tract (GIT) skin and eyes

90
Q

What is Epithelial tissue and 6 functions

A

It is closely packed cells that provide

  • Protection
  • absorption
  • filtration
  • excretion
  • secretions
  • sensory reception
91
Q

What are the 2 types of epithelial tissue

A

Covering and glandular epithelium

92
Q

What are tissues

A

Groups of cells that work together to perform a function

93
Q

What are Organs

A

Groups of tissues working together

94
Q

What are systems

A

Related organs that have a conman function

95
Q

Describe the structure of Epithelial tissue

A

Closely packed cells arranged in continuous sheets.

Either in a single layer - simple epithelia

Double layered - stratified epithelia

96
Q

What are the 2 glandular epithelium glands called and what is their function

A

Exocrine glands - secrete products through ducts onto an epithelial surface e.g sweat glands, sebum, sweat, enzymes milk,

Endocrine glands - secretes hormones directly into the blood. E.g hormones

97
Q

Name an organ that has both endocrine and exocrine glands and what does it do

A

Pancreas - exocrine releases enzymes to help us break down foods. Endocrine releases hormones that regulate blood glucose levels

98
Q

What is the most abundant tissue in the body

A

Connective tissue

99
Q

Where do we find connective tissues

A

Most Bone and cartilage for support. Other types are fluid such as blood

100
Q

What are the 2 basic elements that make up connective tissue

A

Extra cellular Matrix and cells widely spaced apart

101
Q

What is extra cellular matrix formed of

A

Ground substance and protein fibres

102
Q

What is ground substance where is it found and what does it do.

A

Found between cells and helps determine the cells functionality. It consists of water, hyaluronic acid and chondroitin sulphate

103
Q

What are the protein fibres in connective tissue

A

Collagen and Elastic

104
Q

Describe the structure of cells in connective tissue and what do they do

A

Cells are widely spaced and they synthesise protein fibres, fat cells and white blood cells

105
Q

What is the job of fibroblasts

A

Secrete protein fibres to make collagen and elastic fibres. Active in repair and healing

106
Q

Give 4 characteristics of collagen fibres

A

Made from protein collagen
Fibres are very strong
Found especially in bone ligaments and tendons.
Occur in parallel bundles for extra strength

107
Q

Give 4 characteristics of Elastic fibres

A

Made from the protein Elastin
Strong but stretchy to allow tissue to go back to original size
Smaller in diameter to collagen fibres
Found in lung tissue skin and blood vessel walls

108
Q

What does Genitourinary mean

A

organs of the reproductive system and urinary system

109
Q

What are membranes

A

Flat sheets that cover and line areas of the body

110
Q

What are the 4 types of membrane

A

Cutaneous
Mucus
Synovial
Serous

111
Q

Where is the Mucous membrane found

A

It is the moist lining for the alimentary, genitourinary, and respiratory tract.

112
Q

The xxxxxx layer of Mucous membrane contains xxxxxx cells that produce and xxxxx mucus a slimy fluid that? - give 2 examples

A

Epithelial layer
Goblet Cells
Excrete

  1. Protects the lining membrane from chemical/mechanical injury e.g stomach
  2. Traps foreign particles in the respiratory tract before they are swept away by Cilia
113
Q

What cavities do Serous membranes line

A

Cavities that do not open to the exterior

114
Q

Describe the structure of Serous Membrane

A

It is double layered containing inner (visceral) layer and outer (parietal) layer. Between the layers it is filled with Serous fluid. This allows the organ to glide freely without friction.

115
Q

What are the names of the 3 Serous membranes in the body and where is each one found.

A

Pericardium - Surrounding the heart
Pluera - Thoracic cavity and lungs
Peritoneum - Abdominal cavity surrounding abdominal organs and some pelvic organs

116
Q

Define Synovial membranes

A

Line cavities of freely flowing joints and contain cells called synovialcytes that secrete the synovial fluid.

Synovial fluid lubricates the movable joint cavities as well as the surrounding joints and tendons that could be injured if bone were to rub together e.g the wrist

117
Q

What is the skins membrane called

A

Cutaneous membrane

118
Q

What does parietal mean

A

Walls of a cavity

119
Q

What does visceral refer to

A

Organs

120
Q

Explain the role of goblet cells

A

Produce and secrete mucus a slimy fluid that protects the lining membrane and traps foreign particles in the respiratory tract before being swept away by clila

121
Q

What is the alimentary tract

A

tube of the digestive system that goes from the mouth to the anus (covered in Serous membrane)

122
Q

What is the alimentary tract

A

tube of the digestive system that goes from the mouth to the anus (covered in Serous membrane)

123
Q

What are the 8 connective tissue functions

A

Gives structural framework (bone and Cartilage)
Transports nutrients and waste
Protection for vital organs
Support and interconnection tendons and ligaments etc
Insulation (adipose tissue)
Energy Store
Production of blood and lymphatic cells (adipose tissue, bone marrow)
Defence and repair (blood and lymph)

124
Q

Name 3 white blood cells and what they do

A

Macrophages - engulf foreign cells (phagocytes)
Lymphocytes - produce antibodies
Mast cells - release inflammatory chemicals

125
Q

What are the 3 cells in connective tissue

A

Fibroblasts
Adipocytes
White blood cells

126
Q

Function of Fibroblasts

A

Secrete protein fibres to make collagen and elastic fibres. Active in repair and healing

127
Q

Function of Adipocytes

A

Store Triglycerides (Fat)

Biomedicine (1 decks)

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