JVD 2020 Development and Evaluation of a Novel Oral Mucoadhesive Ointment Containing Pomegranate Peel Extract as an Adjuvant for Oral Hygiene of Dogs Flashcards
In 2020 JVD
Development and Evaluation of a Novel Oral Mucoadhesive Ointment Containing Pomegranate Peel Extract as an Adjuvant for Oral Hygiene of Dogs
by Silva
What was the objective and what is the product name?
The objective of the present study was to develop a mucoadhesive ointment formulation that contained pomegranate extract for use in the oral cavity of dogs, with the aim of improving their oral hygiene
The hydroalcoholic extracts of pomegranate peels was incorporated in 3 concentrations.
Name: Orabase
In 2020 JVD
Development and Evaluation of a Novel Oral Mucoadhesive Ointment Containing Pomegranate Peel Extract as an Adjuvant for Oral Hygiene of Dogs
by Silva
What formulation was most suitable?
The formulation containing 25.0% w/w of the extract was considered most suitable for the intended use
In 2020 JVD
Development and Evaluation of a Novel Oral Mucoadhesive Ointment Containing Pomegranate Peel Extract as an Adjuvant for Oral Hygiene of Dogs
by Silva
What breed was studied?
Twelve Labrador retriever dogs were used (7 females and 5 males), aged 1 year and with an average weight of 28.0 kg.
In 2020 JVD
Development and Evaluation of a Novel Oral Mucoadhesive Ointment Containing Pomegranate Peel Extract as an Adjuvant for Oral Hygiene of Dogs
by Silva
Described the way Orabase was made and the concentrations?
Phase 1 was prepared by dispersing the gelling agents (CMC-Na, pectin, and gelatin) in distilled water in which the other excipients had previously been dissolved. The dispersion was heated (60°C) under continuous stirring until a gel formed (FISATOM, model 713D, Brazil). Phase 2 was obtained by melting the required amount of polyethylene in liquid paraffin in a 60°C water bath (ETHIK TECHNOLOGY, model 208-1D, Brazil). The phases were mixed, and a soft orabase was formed after cooling. Bacon flavoring was incorporated at 0.5% w/w and the formulation was labeled ORA. The pomegranate extract was added using a mortar and pestle, in proportions of 12.5%, 25.0%, and 37.5% w/w. The products were named ORA1, ORA2, and ORA3, respectively. Orabase without preservative (ORAWP) was also prepared for use as a control.
