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Clinical Presentation Acute hemolysis
Fever, pain, Hypotension, rapid onset
Major Complications Acute hemolysis
DIC, Renal failure, Shock
Causes acute reaction hemolysis
Complement activation
Essential lab tests Acute hemolysis
Clerical/visual checks, ABO re type, Test for hemolysis
Management for acute hemolysis
Treat DIC and shock, support renal functionP
Prevention Acute hemolytic
System designs to avoid clerical errors
Clinical presentation Delayed hemolysis
Mild jaundice, unexplained H/H dropMajor
Major complications Delayed hemolysis
none
Causes delayed hemolysis
anamnestic
essential lab tests delayed hemolysis
DAT, H/H, bili, haptoglobin
Management delayed hemolysis
provide antigen negative units
Prevention delayed hemolysis
system designed to prevent clerical and technical errors
Delayed antibodies
Kidd, Duffy, Kell, MNS
Acute antibodies
ABO, Rh, Kell
FNHTR
Most often called
Caused by HLA reactions on WBC